Title:
GABA-B受容体モジュレーター
Document Type and Number:
Japanese Patent JP2009521430
Kind Code:
A
Abstract:
The present invention relates to novel imidazole derivatives having a positive allosteric GABAB receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). The compounds are represented by the general formula (I) wherein R1, R2, R3 and R4 are as defined in the description. For example, R1 may be phenyl, R2 may be dimethylamino pyrrolidin-1-yl, R3 may be alkoxy and R4 may be alkyl, ai arylalkyl, aryloxyalkyl, aryloxy or heterocyclylalkyl.
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Inventors:
Audeau bauer
Wayne Bralesford
Linda Gustavson
Thor Svenson
Wayne Bralesford
Linda Gustavson
Thor Svenson
Application Number:
JP2008547167A
Publication Date:
June 04, 2009
Filing Date:
December 21, 2006
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D233/90; A61K31/417; A61K31/4172; A61K31/4178; A61K31/4184; A61K31/4192; A61K31/4245; A61K31/437; A61K31/4439; A61K31/454; A61K45/00; A61P1/00; A61P1/04; A61P1/14; C07C279/28; C07C335/32; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/14; C07D471/04
Domestic Patent References:
| JPH08500121A | 1996-01-09 | |||
| JP2001506664A | 2001-05-22 | |||
| JPS56161364A | 1981-12-11 |
Foreign References:
| WO2005066137A1 | 2005-07-21 | |||
| GB1253332B |
Attorney, Agent or Firm:
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi
Chika Takagi
Shoji Miwa
Noriyuki Takebayashi
Chika Takagi