Title:
DOUBLE ACYLATED GLP-1 DERIVATIVE HAVING LINKER
Document Type and Number:
Japanese Patent JP2016188246
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a derivative of analogue of glucagon-like peptide 1(GLP-1).SOLUTION: There is provided a derivative of GLP-1 analogue, in which the analogue contains a first K residue at a position corresponding to position 18 of GLP-1(7-37), a second K residue at another position, and change of up to 12 amino acids compared to GLP-1(7-37), the derivative contains two extended portions severally adhered to the first and second K residue via a linker, the extended portions are selected from Chem.2:HOOC-CH-O-(CH)-CO-and Chem.1:HOOC-(CH)-CO-, and the linker is a derivative containing Chem.3:-NH-(CH)-CH[(CH)-NH]-CO-, or pharmaceutically acceptable salt, amide, or ester thereof.SELECTED DRAWING: None
Inventors:
JACOB KOFOED
LAU JESPER
LINDEROTH LARS
GARIBAY PATRICK WILLIAM
KRUSE THOMAS
LAU JESPER
LINDEROTH LARS
GARIBAY PATRICK WILLIAM
KRUSE THOMAS
Application Number:
JP2016151098A
Publication Date:
November 04, 2016
Filing Date:
August 01, 2016
Export Citation:
Assignee:
NOVO NORDISK AS
International Classes:
C07K14/605; A61K38/00; A61K47/48; A61P1/00; A61P1/14; A61P3/06; A61P3/10; A61P9/00; A61P15/08; A61P43/00
Foreign References:
| WO1999043706A1 | 1999-09-02 | |||
| WO2009083549A1 | 2009-07-09 | |||
| WO2009030771A1 | 2009-03-12 | |||
| WO2009042922A2 | 2009-04-02 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe
Previous Patent: A new preparing method of an amino acid derivative
Next Patent: A compound and a constituent for cancer medical treatment
Next Patent: A compound and a constituent for cancer medical treatment