NOVEL PROCESS FOR PREPARATION OF AMINO ACID DERIVATIVES

Title:

NOVEL PROCESS FOR PREPARATION OF AMINO ACID DERIVATIVES

Document Type and Number:

Japanese Patent JP2016188245

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide an alternative process for preparation of amino derivatives.SOLUTION: In particular, the present application relates to an improved process for manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, which is useful as an anticonvulsive drug. In a particular aspect, the present invention relates to a process of manufacture of optically enriched (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (I) comprising resolution of 2-acetamido-N-benzyl-3-methoxypropion-amide (II).SELECTED DRAWING: None

Inventors:

DIDIER BOUVY
ALAIN MERSCHAERT
VERONIQUE PINILLA
JOERG HAMANN
RALF KANZLER
ANTOINE THOMAS

Application Number:

JP2016149961A

Publication Date:

November 04, 2016

Filing Date:

July 29, 2016

Export Citation:

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Assignee:

UCB PHARMA GMBH

International Classes:

C07C231/20; C07C237/22

Domestic Patent References:

JP2008514669A	2008-05-08
JP2009520832A	2009-05-28
JP2007510630A	2007-04-26

Foreign References:

US5773475A	1998-06-30
US5773475A	1998-06-30

Other References:

JOURNAL OF MEDICINAL CHEMISTRY, vol. 39(9), JPN6017022164, 1996, pages 1907 - 1916
日本化学会, 光学異性体の分離［季刊　化学総説　NO.6］　, JPN6017022165, 10 June 1999 (1999-06-10)
JOURNAL OF MEDICINAL CHEMISTRY, vol. 39(9), JPN6017022164, 1996, pages 1907 - 1916
日本化学会, 光学異性体の分離［季刊　化学総説　NO.6］　, JPN6017022165, 10 June 1999 (1999-06-10)

Attorney, Agent or Firm:

Asamura patent office

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