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Title:
免疫不全の非ヒト宿主におけるヒトマクロファージの生成
Document Type and Number:
Japanese Patent JP2019508014
Kind Code:
A
Abstract:
本発明は、ヒト免疫系を用いて再構成された、免疫不全の非ヒト宿主におけるヒトマクロファージの生成を刺激する非抗ヒト抗体の使用に関する。ヒト異種移植片を用いたそのような生成方法及び宿主モデル、並びにがんの免疫療法の評価のためのそれらの使用も含まれる。【選択図】図４

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Inventors:
Eckman, Yang
Hove's, Sabine
Wreath, carora
Application Number:
JP2018527902A
Publication Date:
March 28, 2019
Filing Date:
November 28, 2016
Export Citation:
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Assignee:
Ef Hoffman-La Roche Akchengezel Shaft
International Classes:
A01K67/027; C12N5/071
Domestic Patent References:
JPH10504454A1998-05-06
Other References:
NATURE BIOTECHNOLOGY, vol. 32, no. 4, JPN6020027551, 2014, pages 364 - 372, ISSN: 0004458145
BLOOD, vol. 118, JPN6020027552, 2011, pages 3119 - 3128, ISSN: 0004458146
BLOOD, vol. 116, JPN6020027553, 2010, pages 3955 - 3963, ISSN: 0004458147
CANCER CELL, vol. 25, JPN6020027554, 2014, pages 846 - 859, ISSN: 0004458148
BLOOD, vol. 119, JPN6020027555, 2012, pages 1810 - 1820, ISSN: 0004458149
JOURNAL OF IMMUNOLOGY, vol. 191, JPN6020027556, 2013, pages 3192 - 3199, ISSN: 0004458150
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation



 
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