Title:
GLUCAGON-LIKE PROTEIN-1 RECEPTOR (GLP-1R) AGONIST COMPOUND
Document Type and Number:
Japanese Patent JP2012184232
Kind Code:
A
Abstract:
To provide a glucagon-like protein 1 receptor targeting compound, which comprises glucagon-like protein 1 receptor targeting agent-linker conjugates linked to a combining site of an antibody, and to provide various uses of the compound including a method to prevent or treat diabetes or diabetes-related conditions.
The present invention relates to a novel compound that promotes insulin secretion and decreases a blood glucose level, and to methods of producing and using the compound. In particular, the present invention provides a compound that binds to a glucagon-like protein 1 receptor (GLP-1R) and activates the receptor.
Inventors:
BRADSHAW CURT
SAKAMURI SUKUMAR
FU YANWEN
OATES BRYAN
DESHARNAIS JOEL
TUMELTY DAVID
SAKAMURI SUKUMAR
FU YANWEN
OATES BRYAN
DESHARNAIS JOEL
TUMELTY DAVID
Application Number:
JP2012089113A
Publication Date:
September 27, 2012
Filing Date:
April 10, 2012
Export Citation:
Assignee:
COVX TECHNOLOGIES IRELAND LTD
International Classes:
C07K14/605; A61K31/155; A61K31/195; A61K31/64; A61K38/00; A61K38/26; A61K45/00; A61P3/10; A61P43/00; C07K16/26; C12N15/09
Domestic Patent References:
| JP5009376B2 | 2012-08-22 |
Foreign References:
| WO2004110472A2 | 2004-12-23 | |||
| WO2006036834A2 | 2006-04-06 | |||
| WO2005058958A2 | 2005-06-30 | |||
| WO2006094269A2 | 2006-09-08 |
Attorney, Agent or Firm:
▲高▼橋 宏次
佐藤 眞紀
四本 能尚
室伏 良信
宮澤 純子
龍田 美幸
佐藤 眞紀
四本 能尚
室伏 良信
宮澤 純子
龍田 美幸