To provide a heat-resistant heat dissipation sheet hardly deteriorated, and capable of keeping sufficient flexibility even when used at high temperature of 250-300°C.

This heat-resistant heat dissipation sheet contains a binder formed of a rubber-like elastic body having a fluorinated polyether skeleton as a main chain, and a thermally-conductive filler. The heat-resistant heat dissipation sheet is manufactured by mixing a liquid fluorinated polyether and the thermally-conductive filler with each other and thereafter reactively hardening them, and the 10% compressive load of the sheet is ≤100 N/cm2.