Title:
ヘテロアリール化合物およびその使用
Document Type and Number:
Japanese Patent JP7171057
Kind Code:
B2
Abstract:
The application is directed to compounds of formula (I): and their salts and solvates, wherein R1, R2, R3, A1, A2, A3, and n are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of a lysosomal storage disease, such as Gaucher's, and other diseases or disorders that are synucleinopathies.
Inventors:
Garcia Corazo, Ana Maria
Barril Alonso, Xavier
Kubero Holder, Elena
Leves Villaplana, Marc
Roberts, Ricardo Spring
Barril Alonso, Xavier
Kubero Holder, Elena
Leves Villaplana, Marc
Roberts, Ricardo Spring
Application Number:
JP2019535810A
Publication Date:
November 15, 2022
Filing Date:
December 28, 2017
Export Citation:
Assignee:
Minorix Therapeutics Ese Ele.
International Classes:
C07D213/74; A61K31/44; A61K31/505; A61K31/506; A61P25/00; A61P25/16; A61P25/28; A61P43/00; C07D239/48; C07D401/06; C07D401/12; C07D403/06; C07D405/12
Domestic Patent References:
| JP2006506458A | ||||
| JP2015535225A | ||||
| JP41005097B1 | ||||
| JP2008535866A | ||||
| JP2011522894A |
Foreign References:
| CN105412114A | ||||
| WO2016133446A1 | ||||
| WO2016168420A1 | ||||
| WO2012035055A1 | ||||
| WO2015123398A1 |
Other References:
RN 1556118-00-3 REGISTRY,DATABASE REGISTRY [ONLINE] Retrieved from STN,2014年02月26日,検索日:27 OCT 2021
Muvva, Charuvaka et al.,Structure-based virtual screening of novel, high-affinity BRD4 inhibitors,Molecular BioSystems,2014年,(2014), 10(9), 2384-2397
Shen, Mingyun et al.,Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations,Molecular BioSystems,2013年,(2013), 9(3), 361-374
辻川輝昭他,複素環化合物の研究(第1報) 1, 3, 5-Triazine誘導体の合成と一般薬理作用について そのI,薬学雑誌,1975年,(1975), 95(5), 499-511
Shapiro, Seymour L. et al.,Guanamines. II. Oxyalkylguanamine anticonvulsants,Journal of the American Chemical Society,1959年,(1959), 81, 3996-4000
Muvva, Charuvaka et al.,Structure-based virtual screening of novel, high-affinity BRD4 inhibitors,Molecular BioSystems,2014年,(2014), 10(9), 2384-2397
Shen, Mingyun et al.,Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations,Molecular BioSystems,2013年,(2013), 9(3), 361-374
辻川輝昭他,複素環化合物の研究(第1報) 1, 3, 5-Triazine誘導体の合成と一般薬理作用について そのI,薬学雑誌,1975年,(1975), 95(5), 499-511
Shapiro, Seymour L. et al.,Guanamines. II. Oxyalkylguanamine anticonvulsants,Journal of the American Chemical Society,1959年,(1959), 81, 3996-4000
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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