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Title:
HETEROCYCLIC COMPOUND HAVING ANGIOTENSIN II ANTAGONISM
Document Type and Number:
Japanese Patent JP2001328988
Kind Code:
A
Abstract:

To provide a heterocyclic compound having potent angiotensin II antagonism, therefore useful as a therapeutic agent for hypertension or the like.

This heterocyclic compound is shown by formula I [R1 is a hydrocarbon residue which may be bound via a heteroatom and substituted; R2 is an anion-forming group or a group convertible to an anion; R3 is a (substituted) aromatic hydrocarbon residue or (substituted) heterocyclic group containing a heteroatom; X indicates that R3 and W are bound to each other either directly or via a spacer with ≤2 atomic chains; W is a (substituted) aromatic hydrocarbon residue or (substituted) heterocyclic group containing a heteroatom; (a), c and d are each 1 or 2 (substituted) carbon atom(s) or heteroatom(s); b and e are each a (substituted) carbon atom; the broken line indicates that one double bond exists; n is 1-2; and when (a) is a (substituted) carbon atom, R1 and (a) are bound to each other to form a group of formula II which may be a ring].


Inventors:
NAKA TATSUHIKO
INADA YOSHIYUKI
Application Number:
JP2001159745A
Publication Date:
November 27, 2001
Filing Date:
April 15, 1992
Export Citation:
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Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
A61K31/415; A61K31/4178; A61K31/4184; A61K31/4188; A61K31/4196; A61K31/435; A61K31/437; A61K31/44; A61K31/4427; A61K31/443; A61K31/4439; A61K31/50; A61K31/505; A61K31/517; A61K31/519; A61K31/52; A61K31/522; A61P9/00; A61P9/10; A61P9/12; A61P13/02; A61P13/12; A61P15/00; A61P43/00; A61K31/41; C07D401/06; C07D401/14; C07D403/06; C07D403/10; C07D403/12; C07D403/14; C07D405/14; C07D471/04; C07D473/28; C07D473/30; C07D487/04; C07D495/04; (IPC1-7): C07D401/06; A61K31/41; A61K31/4178; A61K31/4184; A61K31/4188; A61K31/4196; A61K31/44; A61K31/4439; A61K31/517; A61K31/519; A61K31/52; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P43/00; C07D401/14; C07D403/10; C07D403/12; C07D403/14; C07D405/14; C07D471/04; C07D487/04; C07D495/04
Attorney, Agent or Firm:
Kaoru Aoyama (4 people outside)