Title:
第IXA因子阻害剤としての複素環式化合物
Document Type and Number:
Japanese Patent JP5504259
Kind Code:
B2
Abstract:
The present invention relates to novel heterocyclic compounds of Formulae I:
as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder.
More Like This:
Inventors:
Clasby, Martin Sea.
Greenlee, William Jay.
Chakkala Manil, Samuel
Xia, Yang
Gao, Xiao Bang
Shellier, Mariappan Buoy.
Eagan, Keith A.
Baccaro, Henry
Chan, Tin-Yau
Macrickrick, brian
One, Li Yuan
Pu, Haiyan
Greenlee, William Jay.
Chakkala Manil, Samuel
Xia, Yang
Gao, Xiao Bang
Shellier, Mariappan Buoy.
Eagan, Keith A.
Baccaro, Henry
Chan, Tin-Yau
Macrickrick, brian
One, Li Yuan
Pu, Haiyan
Application Number:
JP2011510610A
Publication Date:
May 28, 2014
Filing Date:
May 18, 2009
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07D401/14; C07D403/04; C07D403/14; C07D487/04; A61K31/415; A61K31/4155; A61K31/4178; A61K31/4184; A61K31/4188; A61K31/4192; A61K31/422; A61K31/423; A61K31/4439; A61K31/454; A61K31/4709; A61K31/496; A61K31/5377; A61K31/55; A61K45/00; A61P7/02; A61P9/06; A61P9/10; C07D231/18; C07D401/04; C07D403/12; C07D413/04; C07D413/14
Domestic Patent References:
| JP2005509633A |
Foreign References:
| WO2009140342A1 |
Other References:
VIJAYKUMAR D,DISCOVERY OF NOVEL HYDROXY PYRAZOLE BASED FACTOR IXA INHIBITOR,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,ELSEVIER SCIENCE,2006年 5月15日,V16 N10,P2796-2799
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita