PURPOSE: To obtain the subject derivative excellent in serotonin IA receptor agonistic action, sedative action on mental stress, hallucination inhibitory action, having only a slight side effect such as sleepiness, etc., useful for treating and preventing anxiety, depression, hypertension, etc.
CONSTITUTION: This derivative (salt) is shown by formula I or formula II [R1 is CO-R2 (R3 is a 1-7C alkyl, a 3-6C cycloalkyl, etc.); R2 is H or forms a group of formula III, etc., with R1 and N; R6 is a (substituted) 6-14C aryl, etc.; X is methylene or O; (m) is 2-6] such as 3-(4-phthalimidobutyl)-2,3,4,4a,5,6- hexahydro-1H-pyrazino[1,2-a]quinoline-dihydrochloride. The derivative is obtained by reacting a compound of formula IV with a compound of formula V in an inert solvent in the presence or absence of a base (preferably in the presence of the base).
AIZAWA YUICHI
SAFUKU NAOZUMI
SAKAI JUNICHI
TONOHIRO TOSHIYUKI
SUGIMOTO MASAHIKO
HARA TAKAO
HISAMOTO MARIE
HONMA HIROSHI
KOYAMA KAZUO
