To provide a method for judging highly metastatic stomach cancer, to provide a kit therefor, and to provide a method for screening a highly metastatic stomach cancer inhibitor.
A highly metastatic human stomach cancer culture cell strain having a high peritoneum metastatic ability is produced from a human stomach cancer culture cell strain, and the mRNA expressions of the strain before and after the acquisition of the metastatic ability were comprehensively compared and examined with exon microarray. Consequently, it is found that a new exon sequence of DNAJC12 (DnaJ (Hsp40) homolog, subfamily C, member 12), ULBP1 (UL16 binding protein 1), and XAF1 (XIAP associated factor-1) is identified, and a splicing variant containing a region encoded by the new exon DNA sequences is specifically strongly expressed in the high metastatic strain. In addition, it is found that the new variant of ULBP1 is expressed not only in stomach cancer cells but also in pancreatic cancer, large intestinal cancer or breast cancer cells.
COPYRIGHT: (C)2010,JPO&INPIT
Toru Mochizuki
Keiichi Oshima
Keiichi Hatakeyama
| JP2003088388A |
| WO2006110593A1 | ||||
| WO2005044075A1 | ||||
| US6812339 |
Seiji Ozawa
Large High Toshiko
High Kazuya Tsu
Makoto Horiuchi