Title:
ヒストン脱アセチル化酵素の阻害剤
Document Type and Number:
Japanese Patent JP2008505969
Kind Code:
A
Abstract:
The present invention relates to hydroxamic acid derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases. Further, the compounds of the present invention have antiprotozoal properties.
More Like This:
| WO/1994/024096 | HYDROXAMIC ACIDS AND HYDROXAMIC ACID ETHERS AND THEIR USE AS COMPLEXING AGENTS |
| WO/1994/027965 | NOVEL 1-PHENYLALKANONE 5-HT4 RECEPTOR LIGANDS |
| WO/2005/053628 | USE OF OSTEOPONTIN IN DENTAL FORMULATIONS |
Inventors:
Chakra Balti, Prasoon Kay
Kuo, Howard
Machines, JAM
Mink, peter tay
Kuo, Howard
Machines, JAM
Mink, peter tay
Application Number:
JP2007521530A
Publication Date:
February 28, 2008
Filing Date:
July 08, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07C259/10; A61K31/18; A61K31/381; A61K31/4155; A61K31/4184; A61K31/42; A61K31/423; A61K31/4245; A61K31/426; A61K31/428; A61K31/4436; A61K31/4453; A61K31/47; A61K31/5375; A61P9/00; A61P25/00; A61P25/18; A61P33/02; A61P35/00; A61P43/00; C07C311/21; C07C311/29; C07C311/44; C07D215/36; C07D215/38; C07D235/26; C07D261/10; C07D263/56; C07D271/12; C07D277/20; C07D277/46; C07D277/68; C07D277/74; C07D295/16; C07D333/38; C07D333/72; C07D409/04; C07D409/12; C07D413/04; C12N9/14; C12N9/99
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura