Title:
HISTONE DEACETYLASE INHIBITORS
Document Type and Number:
Japanese Patent JP2020019814
Kind Code:
A
Abstract:
To provide compounds and methods for inhibiting histone deacetylase enzymes ("HDAC") (e.g., HDAC1, HDAC2 and HDAC3).SOLUTION: The invention provides a compound with a structure of formula (II) or a pharmaceutically acceptable salt thereof. (In the formula, Rrepresents H or F; Rrepresents H, Cl or F; and Het represents a heterocyclic group selected from among oxetanyl, azetidinyl, piperidinyl and 8-azabicyclo[3.2.1]octanyl.)SELECTED DRAWING: None
More Like This:
Inventors:
VINCENT JACQUES
JAMES R RUSCHE
PEET NORTON P
JASBIR SINGH
JAMES R RUSCHE
PEET NORTON P
JASBIR SINGH
Application Number:
JP2019188049A
Publication Date:
February 06, 2020
Filing Date:
October 11, 2019
Export Citation:
Assignee:
BIOMARIN PHARM INC
International Classes:
C07D205/06; A61K31/337; A61K31/397; A61K31/404; A61K31/439; A61K31/4427; A61K31/445; A61K31/4545; A61P21/00; A61P21/02; A61P21/04; A61P25/00; A61P25/14; A61P25/28; A61P25/30; A61P29/00; A61P31/12; A61P35/00; A61P43/00; C07D211/70; C07D305/10; C07D401/06; C07D403/06; C07D471/08
Domestic Patent References:
| JP2007530459A | 2007-11-01 |
Foreign References:
| WO2012118782A1 | 2012-09-07 | |||
| WO2014152444A1 | 2014-09-25 |
Other References:
YANYANG LI, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. V23 N1, JPN5016003660, 1 January 2013 (2013-01-01), pages 179 - 182, ISSN: 0004381745
DOKMANOVIC MILOS, MOLECULAR CANCER RESEARCH, vol. V5 N10, JPN5016003661, 1 October 2007 (2007-10-01), pages 981 - 989, ISSN: 0004381746
DOKMANOVIC MILOS, MOLECULAR CANCER RESEARCH, vol. V5 N10, JPN5016003661, 1 October 2007 (2007-10-01), pages 981 - 989, ISSN: 0004381746
Attorney, Agent or Firm:
Mizuno Yuuki
Etsu Tamai
Etsu Tamai