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Title:
Hosuhoji esterase 9A as a marker of a prostatic cancer
Document Type and Number:
Japanese Patent JP5918694
Kind Code:
B2
Abstract:
The present invention relates to phosphodiesterase 9A (PDE9A) for use as a marker for prostate cancer, and the use of PDE9A as a marker for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer. The present invention also relates to a composition for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer, a corresponding method and immunoassay, a method for diagnosing, monitoring or prognosticating hormone-resistant prostate cancer vs. hormone-sensitive prostate cancer, a corresponding immunoassay, a method of data acquisition, an immunoassay for diagnosing, detecting, monitoring or prognosticating prostate cancer or the progression of prostate cancer, a method of identifying an individual for eligibility for prostate cancer therapy, an immunoassay for stratifying an individual or cohort of individuals with a prostate cancer disease, an immunoassay for stratifying an individual with prostate cancer. The present invention further envisages pharmaceutical compositions and their use for the treatment of prostate cancer, in particular hormone-resistant prostate cancer.

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Inventors:
Hoffman Ralph
Howthley Miles Day
Henderson David Jay Pee
Application Number:
JP2012510422A
Publication Date:
May 18, 2016
Filing Date:
May 11, 2010
Export Citation:
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Assignee:
KONINKLIJKE PHILIPS N.V.
International Classes:
C12Q1/68; A61K38/43; A61K38/55; A61K39/395; A61K45/00; A61K48/00; A61K49/00; A61P13/08; A61P35/00; A61P43/00; C12Q1/42; G01N33/574
Domestic Patent References:
JP2001526036A
Foreign References:
WO2004053493A1
WO2004053494A1
WO2004053492A1
Other References:
Biochem.Biophys.Res.Commun.,2003 Feb 14,301(3),p.686-92
Mol.Cell.,2007 Aug 3,27(3),p.380-92
Attorney, Agent or Firm:
Patent Services Corporation m&s Partners



 
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