Title:
LRRK2の調整方法
Document Type and Number:
Japanese Patent JP2010523101
Kind Code:
A
Abstract:
A method for identifying a compound expected to be useful in modulating a LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates the protein kinase activity of a LRRK2 polypeptide on a substrate Ezrin/Radixin/moesin (ERM) family polypeptide and (2) selecting a compound which modulates the LRRK2 polypeptide protein kinase activity. Such a compound may be useful in treating Parkinson's Disease or Parkinsonism. A catalytically active fragment of LRRK2 is identified, requiring the GTPase, COR and kinase domains as well as the WD_40-like motif and C-terminal tail.
Inventors:
Areci, Darlio
Application Number:
JP2010501595A
Publication Date:
July 15, 2010
Filing Date:
April 07, 2008
Export Citation:
Assignee:
Medical research counsel
International Classes:
C12N15/09; A61K45/00; A61P25/16; A61P43/00; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12P9/00; C12P21/02; C12Q1/02; C12Q1/48
Foreign References:
| US20040265849A1 | 2004-12-30 |
Other References:
JPN6013007457; Ｄａｔａｂａｓｅ ＧｅｎＢａｎｋ ［ｏｎｌｉｎｅ］， Ａｃｃｅｓｓｉｏｎ Ｎｏ． ＢＡＥ２８７２８， ＜ｈｔｔｐ：／／ｗｗｗ．ｎｃｂｉ．ｎｌｍ．ｎｉｈ．ｇｏｖ／ｐｒｏｔｅｉｎ／７４２２５８５７？ｓａｔ
Attorney, Agent or Firm:
Hiroshi Arafune
Yoshio Arafune
Yoshio Arafune