Title:
ヒト抗体及びタンパク質
Document Type and Number:
Japanese Patent JP2008528668
Kind Code:
A
Abstract:
The present invention provides composite antibody variable regions or fragments thereof, which show reduced immunogenicity. In particular, composite antibody variable regions for use in humans are provided, in particular variable regions which have been modified to remove one or more T-cell epitopes. Methods for generating such variable regions are also provided.
Inventors:
Jones, timothy, david
Baker, matthew, paul
Baker, matthew, paul
Application Number:
JP2007553693A
Publication Date:
July 31, 2008
Filing Date:
February 03, 2006
Export Citation:
Assignee:
Antitope Limited
International Classes:
C07K16/24; A61K38/00; A61K39/395; A61P29/00; A61P37/04; A61P37/08; C07K16/46; C07K19/00; C12N15/09; C12P21/08
Foreign References:
| WO2003042247A2 | 2003-05-22 | |||
| WO1999053038A2 | 1999-10-21 | |||
| EP0699755A2 | 1996-03-06 | |||
| WO1998052976A1 | 1998-11-26 | |||
| WO2000034317A2 | 2000-06-15 |
Other References:
JPN6011045071; Ｈｙｂｒｉｄｏｍａ ａｎｄ ｈｙｂｒｉｄｏｍｉｃｓ． ２００３， Ｖｏｌ．２２， Ｎｏ．４， ｐ．２４５-２５７
JPN6011045071; Ｈｙｂｒｉｄｏｍａ ａｎｄ ｈｙｂｒｉｄｏｍｉｃｓ． ２００３， Ｖｏｌ．２２， Ｎｏ．４， ｐ．２４５-２５７
JPN6011045071; Ｈｙｂｒｉｄｏｍａ ａｎｄ ｈｙｂｒｉｄｏｍｉｃｓ． ２００３， Ｖｏｌ．２２， Ｎｏ．４， ｐ．２４５-２５７
Attorney, Agent or Firm:
Mieko Kashihara