Title:
ヒドロキサム酸化合物およびその使用方法
Document Type and Number:
Japanese Patent JP2006523693
Kind Code:
A
Abstract:
The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl containing groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety, linked to the hydroxamic acid group through a methylene chain. The hydroxamic acid compounds can be used to treat cancer, for example, brain cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.
Inventors:
Breslow Ronald
Mirror Thomas A.
Belvedere Sandro
Marks Paul A.
Recon Victoria M.
Rifkind Richard A.
Mirror Thomas A.
Belvedere Sandro
Marks Paul A.
Recon Victoria M.
Rifkind Richard A.
Application Number:
JP2006509647A
Publication Date:
October 19, 2006
Filing Date:
April 01, 2004
Export Citation:
Assignee:
Memorial Sloan-Kettering Cancer Center
The Trustees of Columbia University in the City of New York
The Trustees of Columbia University in the City of New York
International Classes:
C07D215/38; A61K31/165; A61K31/166; A61K31/27; A61K31/4427; A61K31/444; A61K31/455; A61K31/47; A61K31/4709; A61K31/4725; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P39/06; A61P43/00; C07C259/06; C07C271/22; C07D211/02; C07D213/72; C07D213/79; C07D213/82; C07D215/48; C07D401/12; A61K
Domestic Patent References:
| JP2006512318A | 2006-04-13 | |||
| JP2005506348A | 2005-03-03 | |||
| JP2005530734A | 2005-10-13 | |||
| JP2005525369A | 2005-08-25 | |||
| JP2007518694A | 2007-07-12 | |||
| JP2003509343A | 2003-03-11 |
Foreign References:
| WO1999019296A1 | 1999-04-22 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi
Previous Patent: ５−ＨＴ１Ｆ作用薬としての（ピペリジニルオキシ）フェニル、（ピペリ...
Next Patent: ［２−（８，９−ジオキソ−２，６−ジアザビシクロ［５．２．０］ノナ...
Next Patent: ［２−（８，９−ジオキソ−２，６−ジアザビシクロ［５．２．０］ノナ...