Document Type and Number:
Japanese Patent JP2005508317
Kind Code:
A
Abstract:
A hydroxyeicosenoic acid analog represented by the following Formula (I), the bond = represents a cis-vinylene group or an ethynylene group; Y represents CH<2>, O or S(O)
wherein p is 0, 1 or 2; m represents an integer of 1 to 4 inclusive; n represents an integer of 0 to 3 inclusive; the sum of m and n is an integer of 3 to 7 inclusive; R<1 >represents a C<1-4 >alkyl group or a C<3-8 >cycloalkyl group; R<2 >represents a hydrogen atom or a methyl group; R<3 >represents COR<4>, a nitrile group, a halogen atom, a tetrazole group or a thiazolidinedione group; R<4 >represents OR<6>, NHR<6>, N(OH)R<6>, NHSO<2>R<5>, glycerol or functionalized glycerols; R<5 >represents a C1-15 alkyl group, a C6-10 aryl group or a C7-14 aryl group substituted with alkyl groups, halogens or amino groups; R<6 >represents a hydrogen, a C1-10 alkyl group or a C1-10 alkyl group substituted with a hydroxyl group, or a pharmaceutically acceptable salt or hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.
Inventors:
John Earl Fork
Noriyuki Miyata
Naoya Ono
Chonan Gudori
Hitomi Hirano
Yoshihisa Toda
Toru Tanami
Okuyama Shigeru
Application Number:
JP2003528488A
Publication Date:
March 31, 2005
Filing Date:
September 09, 2002
Assignee:
Taisho Pharmaceutical Co., Ltd.
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
A61K31/047; A61K31/08; A61K31/16; A61K31/18; A61K31/185; A61K31/201; A61K31/231; A61K31/275; A61K31/41; A61K31/426; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P11/08; A61P13/12; A61P15/00; A61P15/06; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P37/02; A61P37/06; A61P43/00; C07C33/04; C07C33/044; C07C33/42; C07C59/01; C07C59/42; C07C59/46; C07C59/60; C07D277/20; C07C69/708; C07C69/732; C07C235/28; C07C255/15; C07C255/16; C07C259/06; C07C309/08; C07C309/10; C07C309/20; C07C309/23; C07C309/24; C07C309/68; C07C311/04; C07C311/17; C07C311/51; C07C317/44; C07C323/52; C07C323/66; C07D257/04; C07D277/34; (IPC1-7): C07C59/01; A61K31/047; A61K31/08; A61K31/16; A61K31/18; A61K31/201; A61K31/231; A61K31/275; A61K31/41; A61K31/426; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P11/08; A61P13/12; A61P15/06; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P37/02; A61P37/06; A61P43/00; C07C33/04; C07C33/42; C07C69/732; C07C235/28; C07C255/16; C07C259/06; C07C311/51; C07D257/04; C07D277/20; C07D277/34
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
