Title:
【発明の名称】ある置換された1-アリール-3-ピペラジン-1’-イルプロパノン類
Document Type and Number:
Japanese Patent JPH10509956
Kind Code:
A
Abstract:
Disclosed are compounds of formula I: I or the pharmaceutically acceptable salts thereof wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 independently represent aryl groups; and Y is hydrogen; or Y and R1 or R2 together represent CH2; CH2CH2; CH2O; CH2S forming a five or six membered ring and such ring may be optionally substituted with loweralkyl or phenyl; or pharmaceutically acceptable salts thereof, useful in the treatment of neoplastic diseases, and bacterial or fungal infections, and for preventing or decreasing the production of abnormally phosphorylated paired helical filament (PHF) epitopes associated with Alzheimer's Disease and, therefore for treating Alzheimer's Disease.
Inventors:
De Bernardis, John F.
Kirkman, Daniel Jay.
Zinkowski, Ray Mandpee.
Kirkman, Daniel Jay.
Zinkowski, Ray Mandpee.
Application Number:
JP51711296A
Publication Date:
September 29, 1998
Filing Date:
November 16, 1995
Export Citation:
Assignee:
Malecular Geriatrics Corporation
International Classes:
C07D295/10; A61K31/40; A61K31/445; A61K31/4535; A61K31/495; A61K31/496; A61K31/5377; A61P25/28; A61P31/04; C07D207/48; C07D231/12; C07D233/60; C07D277/20; C07D277/56; C07D307/52; C07D307/81; C07D319/18; C07D327/08; C07D333/38; C07D333/64; C07D333/68; C07D409/04; C07D409/06; (IPC1-7): A61K31/495
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)