Title:
【発明の名称】A-2受容体親和性をもった2-置換アデノシン類
Document Type and Number:
Japanese Patent JPH08502069
Kind Code:
A
Abstract:
Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine agonists are disclosed. From (in vitro) studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity (in vitro) correlates with adenosine receptor activity (in vivo). Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which will enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.
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Inventors:
Pete, Norton Pee.
Bowcharding, David Earl.
Lenz, Nelsen El.
Waintroub, Philip M.
Bowcharding, David Earl.
Lenz, Nelsen El.
Waintroub, Philip M.
Application Number:
JP50905893A
Publication Date:
March 05, 1996
Filing Date:
September 02, 1993
Export Citation:
Assignee:
Merrell Dow Pharmaceuticals Inc.
International Classes:
A61K31/70; A61K31/7042; A61K31/7052; C07H1/00; A61K31/7064; A61P9/12; C07H19/067; C07H19/16; (IPC1-7): C07H19/067; A61K31/70; C07H1/00
Attorney, Agent or Firm:
Katsuro Sasai