Title:
【発明の名称】デメチルエピポドフィロトキシンの製造方法
Document Type and Number:
Japanese Patent JP3231765
Kind Code:
B2
Abstract:
Demethylepipodophyllotoxin- beta -glucosides are prepared by allowing demethylepipodophyllotoxin to react with a 2,3-di-O-ester of a 1-O-trialkylsilyl-4,6-O-alkylidene- beta -D-glucose derivative in the presence of a Lewis acid. The 4,6-O-alkylidene group can be alkylidene, arylalkylidene, or heteroarylalkylidene and the 2,3-ester can be lower alkanoyl or haloacetyl. In a typical embodiment, demethylepipodophyllotoxin is allowed to react with 4,6-O-ethylidene-2,3-di-O-acetyl-1-O-trimethylsilyl- beta -D-glucose in the presence of boron trifluoride etherate to yield etoposide 2'',3''-diacetate.
Inventors:
Allevi pietro
Anastasia Mario
Bigatti Ettore
McDonald Peter
Anastasia Mario
Bigatti Ettore
McDonald Peter
Application Number:
JP50258193A
Publication Date:
November 26, 2001
Filing Date:
July 15, 1992
Export Citation:
Assignee:
Sicole Societe Italiana Corticostero di Es. Pierre.
International Classes:
A61K31/7042; A61K31/7048; A61K31/7135; A61K31/70; A61P35/00; C07H1/00; C07H13/04; C07H17/04; C07H23/00; (IPC1-7): C07H17/04; C07H1/00
Domestic Patent References:
| JP324097A | ||||
| JP5823637A |
Attorney, Agent or Firm:
Ichiro Sugawara