Title:
【発明の名称】シクロオキシゲナーゼ-2の多結合インヒビター
Document Type and Number:
Japanese Patent JP2002517423
Kind Code:
A
Abstract:
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.
Inventors:
Judith, Jay Kevin
Higgins, Deborah El.
Griffin, John H.
Higgins, Deborah El.
Griffin, John H.
Application Number:
JP2000553012A
Publication Date:
June 18, 2002
Filing Date:
June 07, 1999
Export Citation:
Assignee:
Advanced Medicine Incorporated
International Classes:
C07D231/12; A61K31/00; A61K31/341; A61K31/40; A61K31/415; A61K47/48; A61P29/00; A61P43/00; C07C233/36; C07C233/78; C07C237/24; C07C271/20; C07C321/04; C07C323/12; C07C335/08; C07C335/32; C07D207/333; C07D211/58; C07D215/56; C07D233/90; C07D235/30; C07D307/58; C07D401/06; C07D401/12; C07D401/14; C07D405/04; C07D413/14; C07D471/04; C07D471/14; C07D473/00; C07D473/34; C07D475/04; C07D475/08; C07D487/04; C07D487/06; C07D493/04; C07D493/06; C07D498/04; C07D519/00; C07H19/20; C12Q1/26; C12Q1/44; C12Q1/48; C12Q1/533; C40B20/06; C40B30/04; C40B40/04; C40B50/08; G01N33/573; G01N33/68; G01N33/92; C07B61/00; C07D207/32; (IPC1-7): C07D307/58; A61K31/341; A61K31/40; A61K31/415; A61P29/00; A61P43/00; C07D207/333; C07D231/12
Attorney, Agent or Firm:
Shusaku Yamamoto