Title:
【発明の名称】可溶性グアニル酸シクラーゼのアクチベーター
Document Type and Number:
Japanese Patent JP2003513064
Kind Code:
A
Abstract:
Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the activation of soluble guanylate cyclase, wherein: R1 and R2 are the same or different and each represent a C1-C6 alkyl group, or R1 and R2 together form a C3-C6 alkylene group; Z is a C1-C4 alkylene group; P is a direct bond or a moiety -X-, -Y-, -W-, -XY-, -YW- or -XYW-, wherein; W is -O-, -S-, or -NR3, wherein R3 is hydrogen or C1-C6 alkyl; Y is a moiety -U-V- wherein V is a direct bond or a C1-C6 alkylene group and U is -CS-, -CO-, -S(O)2- or -C(=NR)- wherein R is hydrogen, hydroxy or C1-C6 alkyl; X is -O- or -NR6- wherein R6 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl or heteroaryl; and R4 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, a group -R-A wherein R is -(C1-C6 alkyl)-, -(C2-C6 alkenyl)- or -(C2-C6 alkynyl)- and A is aryl, heteroaryl, carbocyclyl or heterocyclyl, or R4 is a group -COR", -CO2R", -S(O)2R" or -CONR'R" wherein R' is hydrogen, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl and R" is aryl, heteroaryl, carbocyclyl or heterocyclyl.
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Inventors:
Selwood, David
Glen, Robert
Reynolds, Karen
Wishart, Grant
Glen, Robert
Reynolds, Karen
Wishart, Grant
Application Number:
JP2001534758A
Publication Date:
April 08, 2003
Filing Date:
November 06, 2000
Export Citation:
Assignee:
University College London
International Classes:
C07D237/32; A61K31/16; A61K31/166; A61K31/17; A61K31/18; A61K31/27; A61K31/341; A61K31/352; A61K31/381; A61K31/402; A61K31/404; A61K31/415; A61K31/426; A61K31/427; A61K31/433; A61K31/4365; A61K31/437; A61K31/4439; A61K31/455; A61K31/465; A61K31/47; A61K31/4709; A61K31/497; A61K31/502; A61K31/505; A61K31/517; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P15/06; A61P15/10; A61P27/02; A61P27/06; A61P43/00; C07C233/08; C07C233/36; C07C233/37; C07C233/40; C07C233/62; C07C233/78; C07C235/34; C07C235/50; C07C235/60; C07C235/78; C07C235/82; C07C235/84; C07C237/40; C07C275/16; C07C275/22; C07C275/24; C07C275/26; C07C275/30; C07C275/36; C07C275/38; C07C275/42; C07C311/13; C07C311/21; C07C311/46; C07C317/36; C07C323/62; C07C323/67; C07D207/16; C07D207/34; C07D209/18; C07D209/22; C07D209/42; C07D213/643; C07D213/80; C07D213/82; C07D215/42; C07D215/52; C07D231/14; C07D231/16; C07D231/40; C07D237/30; C07D239/32; C07D239/38; C07D239/95; C07D241/24; C07D277/20; C07D277/28; C07D277/30; C07D277/56; C07D295/13; C07D307/68; C07D311/24; C07D333/36; C07D333/38; C07D333/40; C07D333/56; C07D333/70; C07D401/12; C07D405/04; C07D409/04; C07D417/04; C07D417/12; C07D471/04; C07D495/04; C07D213/64; (IPC1-7): A61K31/166; A61K31/16; A61K31/17; A61K31/18; A61K31/27; A61K31/341; A61K31/352; A61K31/381; A61K31/402; A61K31/404; A61K31/415; A61K31/426; A61K31/427; A61K31/433; A61K31/4365; A61K31/437; A61K31/4439; A61K31/455; A61K31/465; A61K31/47; A61K31/4709; A61K31/497; A61K31/502; A61K31/505; A61K31/517; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P15/06; A61P15/10; A61P27/02; A61P27/06; A61P43/00; C07C233/08; C07C233/62; C07C233/78; C07C275/22; C07C275/24; C07C275/30; C07C275/36; C07C275/38; C07C311/13; C07C311/21; C07C311/46; C07C317/36; C07D207/16; C07D209/42; C07D213/80; C07D213/82; C07D215/52; C07D231/14; C07D237/32; C07D239/32; C07D239/95; C07D241/24; C07D277/56; C07D277/593; C07D307/68; C07D311/24; C07D333/36; C07D333/40; C07D333/70; C07D401/12; C07D405/04; C07D409/04; C07D417/04; C07D417/12; C07D471/04; C07D495/04
Attorney, Agent or Firm:
Akira Asamura (3 outside)