Title:
【発明の名称】インダン‐、ジヒドロベンゾフラン‐、ジヒドロベンゾチオフエン‐、及びインドリン‐誘導体、その酸付加塩及びその異性体並びにその製造方法
Document Type and Number:
Japanese Patent JP2677588
Kind Code:
B2
Abstract:
Indane-, dihydrobenzofurane-, dihydrobenzothiophene-, and indoline- derivatives of the following formula: wherein X, R<1>, R<2>, R<3> and R<4> are as defined in Claim 1, are effective at presynaptic DA receptors, or both at pre- and postsynaptic DA receptors, indicating usefulness in the treatment of disorders of the central nervous system (CNS) such as schizophrenia or Parkinson's disease. The 1-aminomethyl derivatives of Formula I exist as optical isomers, and the useful effects are often found in the single enantiomers to a different degree. A method for the preparation of compounds of Formula I is described.
Inventors:
Claus Peter Beghese
Yence Cristian Peregard
Yence Cristian Peregard
Application Number:
JP4238888A
Publication Date:
November 17, 1997
Filing Date:
February 26, 1988
Export Citation:
Assignee:
Her Lundbeck Actiezer Scabet
International Classes:
A61K31/13; A61K31/30; A61K31/34; A61K31/343; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61K31/415; C07D209/16; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/505; A61P9/00; A61P25/04; A61P25/18; A61P25/24; A61P25/26; A61P43/00; C07C67/00; C07C213/00; C07C215/46; C07C215/64; C07C217/54; C07C217/74; C07C219/26; C07C219/28; C07C239/00; C07C255/59; C07C271/00; C07C271/42; C07C271/44; C07C271/58; C07C313/00; C07C323/32; C07D209/14; C07D307/81; C07D333/58; C07D401/12; C07D403/12; C07D405/12; C07D409/12; (IPC1-7): C07C215/64; A61K31/34; A61K31/38; C07C217/74; C07C219/28; C07C271/44; C07C271/58; C07D307/81; C07D333/58
Attorney, Agent or Firm:
Esaki Mitsufumi