Title:
GABA受容体に対するリガンドとしてのイミダゾ-トリアジン誘導体
Document Type and Number:
Japanese Patent JP2005529909
Kind Code:
A
Abstract:
A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a -NH- linkage, and substituted on the phenyl ring by one or two further substituents as defined herein, being selective ligands for GABAA receptors, in particular having good affinity for the alpha2 and/or alpha3 and/or alpha5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
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Inventors:
Betty Stay, Michela
Chain Invers, Mark Stuywart
Guts de Acres, Simon Challes
Harlett, David The Ames
Russell, Michael Geoffrey Neil
Street, Leslie Yogyov
Chain Invers, Mark Stuywart
Guts de Acres, Simon Challes
Harlett, David The Ames
Russell, Michael Geoffrey Neil
Street, Leslie Yogyov
Application Number:
JP2004501411A
Publication Date:
October 06, 2005
Filing Date:
May 01, 2003
Export Citation:
Assignee:
Merck Sharp End Dome Limited
International Classes:
A61K31/53; A61P1/08; A61P1/14; A61P13/10; A61P15/00; A61P21/02; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P27/16; C07D487/04; (IPC1-7): C07D487/04; A61K31/53; A61P1/08; A61P1/14; A61P13/10; A61P15/00; A61P21/02; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P25/30; A61P25/32; A61P27/16
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura