Title:
免疫調節剤
Document Type and Number:
Japanese Patent JP2017525753
Kind Code:
A
Abstract:
酸化還元酵素インドールアミン２,３−ジオキシゲナーゼを調節する化合物および該化合物を含む組成物がここに記載される。インドールアミン２,３−ジオキシゲナーゼが介在する癌および免疫関連障害を含む多種多様な疾患、障害および状態の処置および／または予防のための該化合物および組成物の使用も提供される。
Inventors:
Juan Carlos Jaen
Maxim Osipov
Jay Patrick Powers
Hunter Paul Schnatona
James Ross Walker
Mikhail Zibinsky
Maxim Osipov
Jay Patrick Powers
Hunter Paul Schnatona
James Ross Walker
Mikhail Zibinsky
Application Number:
JP2017516640A
Publication Date:
September 07, 2017
Filing Date:
June 05, 2015
Export Citation:
Assignee:
FLEXUS BIOSCIENCES, INC.
International Classes:
C07C259/14; A61K31/155; A61K31/192; A61K31/21; A61K31/235; A61K31/341; A61K31/40; A61K31/426; A61K31/4418; A61K31/445; A61K31/5375; A61K45/00; A61P1/04; A61P1/18; A61P3/06; A61P7/06; A61P9/00; A61P9/10; A61P11/06; A61P13/12; A61P17/04; A61P19/10; A61P21/00; A61P25/00; A61P25/16; A61P25/28; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P33/06; A61P35/00; A61P35/02; A61P37/02; A61P37/08; A61P43/00; C07D207/09; C07D211/34; C07D213/58; C07D277/30; C07D295/155; C07D307/14
Domestic Patent References:
| JP2008540548A | 2008-11-20 | |||
| JP2009520817A | 2009-05-28 | |||
| JP2010504347A | 2010-02-12 | |||
| JPH10506923A | 1998-07-07 | |||
| JPH07330764A | 1995-12-19 |
Foreign References:
| WO2008036643A2 | 2008-03-27 | |||
| US20040234623A1 | 2004-11-25 |
Other References:
MELAGRAKI, GEORGIA; AFANTITIS, ANTREAS; SARIMVEIS, HARALAMBOS; KOUTENTIS, PANAYIOTIS A.; KOLLIAS, GE: "Predictive QSAR workflow for the in silico identification and screening of novel HDAC inhibitors", MOLECULAR DIVERSITY, JPN6018051861, 2009, pages 301 - 311, XP019732283, ISSN: 0004146604, DOI: 10.1007/s11030-009-9115-2
HURD, CHARLES D.; NILSON, MAY E.; WIKHOLM, M. D.: "Hydroximyl chlorides from nitrostyrenes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 72, JPN6018051862, 1950, pages 4697 - 4799, ISSN: 0004146605
BAKER, KENNETH W. J.; HORNER, KATHERINE S.; MOGGACH, STEPHEN A.; PATON, R. MICHAEL; SMELLIE, IAIN A.: "Synthesis of pyranosyl amidoximes by addition of amines to pyranosyl nitrile oxides", TETRAHEDRON LETTERS, vol. 45, JPN6018051863, 2004, pages 8913 - 8916, ISSN: 0004146606
UNO, HITOSHI; KUROKAWA, MIKIO; NATSUKA, KAGAYAKI; YAMATO, YUZURU; NISHIMURA, HARUKI: "Studies on 3-substituted 1,2-benzisoxazole derivatives. I", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 24, JPN6018051864, 1976, pages 632 - 643, ISSN: 0004146607
KATRITZKY, ALAN R.; KHASHAB, NIVEEN M.; KIRICHENKO, NATALIYA; SINGH, ANAMIKA: "Microwave-Assisted Preparations of Amidrazones and Amidoximes", JOURNAL OF ORGANIC CHEMISTRY, vol. 71, JPN6018051865, 2006, pages 9051 - 9056, XP055255367, ISSN: 0004146608, DOI: 10.1021/jo061410u
SANGUINETI, GABRIELLA; LE, HOANG V.; GANEM, BRUCE: "Studies on the synthesis of amidoximes from nitroalkanes", TETRAHEDRON, vol. 67(52), JPN6018051866, 2011, pages 10208 - 10211, ISSN: 0004146609
BOYER, JOSEPH H.; FRINTS, P. J. A.: "Dehydration of amidoximes with and without rearrangement", JOURNAL OF ORGANIC CHEMISTRY, vol. 35, no. 7, JPN6018051867, 1970, pages 2449 - 2450, ISSN: 0004146610
GRUNDMANN, CHRISTOPH; DATTA, SUSHIL KUMAR: "Nitrile oxide. XII. Cycloaliphatic and aliphatic stable nitrile oxide", JOURNAL OF ORGANIC CHEMISTRY, vol. Vol.34 N.6, JPN6018051868, 1969, pages 2016 - 2018, ISSN: 0004146611
KNUNYANTS, I. L.; BYKHOVSKAYA, E. G.; FROSIN, V. N.: "Reaction of hydroxylamine with pseudoolefins", ZHURNAL VSESOYUZNOGO KHIMICHESKOGO OBSHCHESTVA IM. D. I. MENDELEEVA, vol. 9, no. 5, JPN6018051869, 1964, pages 598 - 599, ISSN: 0004146612
HURD, CHARLES D.; NILSON, MAY E.; WIKHOLM, M. D.: "Hydroximyl chlorides from nitrostyrenes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 72, JPN6018051862, 1950, pages 4697 - 4799, ISSN: 0004146605
BAKER, KENNETH W. J.; HORNER, KATHERINE S.; MOGGACH, STEPHEN A.; PATON, R. MICHAEL; SMELLIE, IAIN A.: "Synthesis of pyranosyl amidoximes by addition of amines to pyranosyl nitrile oxides", TETRAHEDRON LETTERS, vol. 45, JPN6018051863, 2004, pages 8913 - 8916, ISSN: 0004146606
UNO, HITOSHI; KUROKAWA, MIKIO; NATSUKA, KAGAYAKI; YAMATO, YUZURU; NISHIMURA, HARUKI: "Studies on 3-substituted 1,2-benzisoxazole derivatives. I", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 24, JPN6018051864, 1976, pages 632 - 643, ISSN: 0004146607
KATRITZKY, ALAN R.; KHASHAB, NIVEEN M.; KIRICHENKO, NATALIYA; SINGH, ANAMIKA: "Microwave-Assisted Preparations of Amidrazones and Amidoximes", JOURNAL OF ORGANIC CHEMISTRY, vol. 71, JPN6018051865, 2006, pages 9051 - 9056, XP055255367, ISSN: 0004146608, DOI: 10.1021/jo061410u
SANGUINETI, GABRIELLA; LE, HOANG V.; GANEM, BRUCE: "Studies on the synthesis of amidoximes from nitroalkanes", TETRAHEDRON, vol. 67(52), JPN6018051866, 2011, pages 10208 - 10211, ISSN: 0004146609
BOYER, JOSEPH H.; FRINTS, P. J. A.: "Dehydration of amidoximes with and without rearrangement", JOURNAL OF ORGANIC CHEMISTRY, vol. 35, no. 7, JPN6018051867, 1970, pages 2449 - 2450, ISSN: 0004146610
GRUNDMANN, CHRISTOPH; DATTA, SUSHIL KUMAR: "Nitrile oxide. XII. Cycloaliphatic and aliphatic stable nitrile oxide", JOURNAL OF ORGANIC CHEMISTRY, vol. Vol.34 N.6, JPN6018051868, 1969, pages 2016 - 2018, ISSN: 0004146611
KNUNYANTS, I. L.; BYKHOVSKAYA, E. G.; FROSIN, V. N.: "Reaction of hydroxylamine with pseudoolefins", ZHURNAL VSESOYUZNOGO KHIMICHESKOGO OBSHCHESTVA IM. D. I. MENDELEEVA, vol. 9, no. 5, JPN6018051869, 1964, pages 598 - 599, ISSN: 0004146612
Attorney, Agent or Firm:
Samejima Mutsumi
Yasushi Morimoto
Nobuhiko Akiyama
Yasushi Morimoto
Nobuhiko Akiyama