Title:
MEP経路遺伝子の不活性化
Document Type and Number:
Japanese Patent JP4526763
Kind Code:
B2
Abstract:
The invention relates to cells and organisms as well as to methods for producing said cells and organisms, according to which intermediates of the mevalonate-independent pathway for isoprenoid biosynthesis (MEP pathway) are enriched by deleting or inactivating genes. The derivatives can also be enriched by using enzyme inhibitors. The enriched intermediates may be used as substrates in enzyme activity tests. The inventive cells and organisms and the enriched intermediates can further be used in the production of medicaments.
Inventors:
Hassan, Yommer
Matthias, Eval
Boran, Altinzicek
Matthias, Eval
Boran, Altinzicek
Application Number:
JP2002592474A
Publication Date:
August 18, 2010
Filing Date:
April 13, 2002
Export Citation:
Assignee:
BIOAGENCY AG
International Classes:
C12N15/09; A61K31/66; A61K31/661; A61K31/665; A61K31/7088; A61K35/66; A61K35/68; A61K35/74; A61K38/00; A61K48/00; A61P1/00; A61P1/16; A61P3/10; A61P5/14; A61P5/38; A61P7/06; A61P11/06; A61P17/00; A61P19/02; A61P19/10; A61P21/04; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P37/02; A61P37/04; A61P37/08; C07G99/00; C07K14/245; C12N5/00; C12N5/07; C12N5/0783; C12N9/24; C12N15/56; C12N15/63; C12P1/00; C12P1/04; C12P9/00
Other References:
J. Immunol., (2001.03), 166, [6], p.3655-3658
J. Bacteriol., (1993), 175, [4], p.1203-1205
Nucleic Acids Res., (1991), 19, [1], p.180
J. Bacteriol., (2000), 182, [20], p.5841-5848
FEMS Immunol. Med. Microbiol., (1999), 25, [4], p.371-378
J. Bacteriol., (1993), 175, [4], p.1203-1205
Nucleic Acids Res., (1991), 19, [1], p.180
J. Bacteriol., (2000), 182, [20], p.5841-5848
FEMS Immunol. Med. Microbiol., (1999), 25, [4], p.371-378
Attorney, Agent or Firm:
Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Yukitaka Nakamura
Noritaka Yokota