INHIBITOR OF CHRONIC INFLAMMATION ACCOMPANYING AGING OR OBESITY, THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR DISEASES ASSOCIATED WITH CHRONIC INFLAMMATION ACCOMPANYING AGING OR OBESITY, DEVICE FOR ASSESSING AFFECTION PROBABILITY, AND SCREENING METHOD

Title:

Document Type and Number:

Japanese Patent JP2015182964

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide an inhibitor and a therapeutic agent or a preventive agent which inhibit chronic inflammation accompanying aging or obesity by inhibiting the increase in the number of PD-1 positive memory T cells, to provide a device for assessing affection probability, and to provide a screening method.SOLUTION: An inhibitor for chronic inflammation accompanying aging or obesity comprises a substance which inhibits the increase in the number of PD-1 positive memory T cells. For the substance, using antibodies which eliminate PD-1 positive memory T cells is preferable. A therapeutic agent or a preventive agent for diseases associated with chronic inflammation accompanying aging or obesity contains the substance which inhibits the increase in the number of PD-1 positive memory T cells as an active ingredient. A device for assessing affection probability of diseases associated with chronic inflammation accompanying aging or obesity has a measurable means for the cell number of PD-1 positive memory T cells in a sample sampled from a subject, and a means for assessing affection probability of diseases associated with chronic inflammation accompanying aging or obesity based on the test result by the measurable means.

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Inventors:

SANO MOTOAKI
NIIMURA TAKESHI

Application Number:

JP2014058581A

Publication Date:

October 22, 2015

Filing Date:

March 20, 2014

Export Citation:

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Assignee:

KEIO GIJUKU

International Classes:

A61K45/00; A61K39/395; A61P3/04; A61P29/00; A61P37/06; A61P43/00; C12M1/34; C12Q1/04

Other References:

生化学, vol. 第84巻第3号, JPN6017044274, 2012, pages 203 - 208

Attorney, Agent or Firm:

Masayuki Masabayashi
Hayashi Ichiyoshi

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