Title:
INHIBITOR OF HIV AND RELATED VIRUS AND INHIBITING METHOD
Document Type and Number:
Japanese Patent JP3383328
Kind Code:
B2
Abstract:
PURPOSE: To provide a compsn. useful to inhibit and/or treat infections by HIV and to treat or inhibit AIDS.
CONSTITUTION: The compsn. contains as an effective component, a compd. expressed by formula I or its salt, or a compd. expressed by formula III or its salt. In the formula I, (n) is 0 to 4; Z is C=Y (Y is O, S), CH2; R11 is formula II (R14 is 3 to 8-member org. monocyclic group containing 0 to 4 heteroatoms, 7 to 10-member org. bicyclic group containing 0 to 5 heteroatoms; R15, R16 are H, alkyl, cycloalkyl, halo, NH, etc.); R12 is H, OH, alkyl, NH2, CN, NO2, etc.; R13 is 3 to 8-member org. monocyclic group containing 0 to 4 heteroatoms, the formula II, etc. In the formula III, R1 is 3 to 8-member org. monocyclic group containing 0 or 4 heteroatoms, etc.; R2 is formula IV (R5 is R1, etc.; R6 to R9 are H, alkyl, cycloalkyl, halo, etc.); R3, R4 are H, OH, alkyl, NH2, CN, carboxy, etc. The compd. is for example, N-(2-phenethyl)-N'-(2-thiazolyl) thiourea.
Inventors:
Peter Thomas Lind
John Michael Morin Jr.
Rolf Norain
Robert John Turnanski
John Michael Morin Jr.
Rolf Norain
Robert John Turnanski
Application Number:
JP22521892A
Publication Date:
March 04, 2003
Filing Date:
July 31, 1992
Export Citation:
Assignee:
MEDIVIR AKTIEBOLAG
International Classes:
A61K31/17; A61K31/41; A61K31/415; A61K31/4166; A61K31/42; A61K31/425; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4427; A61K31/444; A61K31/47; C07C335/04; A61K31/49; A61K31/495; A61K31/4965; A61K31/50; A61K31/505; A61K31/535; A61K31/55; A61K45/06; A61P31/12; A61P31/18; A61P37/02; C07C335/12; C07C335/16; C07C335/22; C07D213/75; C07D213/85; C07D215/38; C07D231/40; C07D233/02; C07D233/84; C07D233/86; C07D233/88; C07D235/30; C07D237/20; C07D237/22; C07D239/10; C07D239/42; C07D241/20; C07D249/14; C07D257/06; C07D263/48; C07D275/03; C07D277/18; C07D277/20; C07D277/38; C07D277/48; C07D277/56; C07D277/82; C07D285/135; C07D307/52; C07D401/04; C07D401/12; C07D403/04; C07D403/12; C07D417/04; C07D417/12; C07D275/02; C07D285/12; (IPC1-7): C07D233/84; A61K31/415; A61K31/44; A61K31/495; A61K31/50; A61K31/505; A61K31/55; A61P37/02; C07D233/86; C07D277/38; C07D277/82; C07D401/04; C07D403/04; C07D417/04
Domestic Patent References:
| JP52128332A | ||||
| JP4828609A | ||||
| JP49171B1 |
Other References:
【文献】米国特許3891769(US,A)
【文献】米国特許3950537(US,A)
【文献】米国特許3950537(US,A)
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)
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