Title:
【発明の名称】ヒト免疫不全ウイルス(HIV-1)複製の阻害
Document Type and Number:
Japanese Patent JP2001520017
Kind Code:
A
Abstract:
The present invention is directed to an HIV-1-regulated antiviral system. The invention provides constructs and methods for transferring an antiviral enzyme into target cells, wherein the enzyme is under HIV-1 regulation. HIV-1 infection of the targeted cells causes the activation of the antiviral enzyme, and results in the inhibition of viral replication. The HIV-1 controlled antiviral approach can be combined with traditional chemotherapeutic approaches, permitting a significant reduction in antiviral drugs, with decreased side effects, and the maintenance of HIV-1 in a true latent state.
Inventors:
Robert J. Suhadnik
Martin Eadelson
Yakono, Kathryn Tea
Martin Eadelson
Yakono, Kathryn Tea
Application Number:
JP2000516047A
Publication Date:
October 30, 2001
Filing Date:
October 15, 1998
Export Citation:
Assignee:
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
International Classes:
C12N15/09; A61K31/513; A61K35/76; A61K45/00; A61K45/06; A61K48/00; A61P31/18; A61P37/04; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/00; C12N9/12; C12N15/86; A61K38/00; (IPC1-7): C12N15/09; A61K31/513; A61K45/00; A61K45/06; A61K48/00; A61P31/18; A61P37/04; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Attorney, Agent or Firm:
Kurahashi Akira