Title:
アスコクロリン誘導体およびＡＭＰＫ活性化剤としてのその使用
Document Type and Number:
Japanese Patent JP6758669
Kind Code:
B2
Abstract:
An object of the present invention is to provide a novel ascochlorin derivative which activates adenosine monophosphate-activated protein kinase (AMPK), and is useful in the treatment or prevention of diseases or conditions that involve AMPK dysregulation. The present invention provides a compound presented by formula I, a pharmaceutically acceptable salt or a solvate thereof.
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Inventors:
Nobuo Shinma
Tatsuo Hoshino
Tatsuo Hoshino
Application Number:
JP2018553638A
Publication Date:
September 23, 2020
Filing Date:
January 04, 2017
Export Citation:
Assignee:
Tatsuo Hoshino
International Classes:
C07C47/575; A61K31/11; A61K31/135; A61K31/15; A61K31/19; A61K31/215; A61K31/337; A61K31/495; A61K31/5375; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P25/28; A61P35/00; A61P43/00; C07C45/52; C07C45/63; C07C49/757; C07C221/00; C07C223/04; C07C249/06; C07C249/08; C07C249/12; C07C251/44; C07C251/48; C07C251/56; C07C251/58; C07C251/66; C07D305/08
Domestic Patent References:
| JP2005225851A |
Foreign References:
| WO2004074236A1 | ||||
| US20140243378 |
Other References:
JEONG, J. H. et al.,4-O-methylascochlorin, methylated derivative of ascochlorin, stabilizes HIF-1a via AMPK activation,Biochemical and Biophysical Research Communications,2011年,Vol. 406,pp. 353-358
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Takumi Terachi
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Takumi Terachi