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Title:
LACTAM AS β-SECRETASE INHIBITOR
Document Type and Number:
Japanese Patent JP2012107029
Kind Code:
A
Abstract:

To provide β-secretase (BACE) inhibitors used as treatment for neurodegenerative and/or neurological disorders such as Alzheimer's disease (AD), cerebral amyloid angiopathy (CM) and prion-mediated diseases.

This invention relates to a 1,8-diazaspiro[4.5]decan-2-one derivative such as a compound 88 expressed by the following formula.


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JPS581779908-(3-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PROPYL)-1- PHENYL-1,3,8-TRIAZASPIRO(4,5)DECAN-4-ONE
Inventors:
BRODNEY MICHAEL AARON
EFREMOV IVAN VIKTOROVICH
HELAL CHRISTOPHER JOHN
O'NEILL BRIAN THOMAS
Application Number:
JP2012009735A
Publication Date:
June 07, 2012
Filing Date:
January 20, 2012
Export Citation:
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Assignee:
PFIZER
International Classes:
C07D471/10; A61K31/438; A61K45/00; A61P25/28; A61P43/00
Foreign References:
WO2008054698A22008-05-08
WO2008030412A22008-03-13
Attorney, Agent or Firm:
Yoshinobu Murofushi
High Hoji Koji
Junko Miyazawa
Noh four
Maki Sato
Tatsuta Miyuki



 
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