Title:
LASER SCANNING METHOD FOR MEASURING IN VIVO AMOUNT OF SPECIFIC SUBSTANCE
Document Type and Number:
Japanese Patent JP2013126443
Kind Code:
A
Abstract:
To provide a laser scanning method for measuring in vivo amount of a specific substance, which can quantitatively and non-invasively measure the concentration and distribution of lutein in ocular fundus.
The laser scanning method for measuring an in vivo amount of a specific substance is characterized in measuring the density of the lutein from a signal intensity level of an anti-stokes ray by causing the wavelength of the anti-Stokes ray to be greater than a wavelength absorption band of a specific substance, shifting the wavelength of a probe light by the amount of shifting in Raman scattering of the specific substance from the wavelength of the anti-Stokes ray, and shifting the wavelength of a Stokes light by the amount of shifting in Raman scattering of the specific substance from the wavelength of the probe light.
Inventors:
WADA TOMOYUKI
TSUBOTA KAZUO
KAMINARI JUNJI
TSUBOTA KAZUO
KAMINARI JUNJI
Application Number:
JP2011276295A
Publication Date:
June 27, 2013
Filing Date:
December 16, 2011
Export Citation:
Assignee:
RIKAGAKU KENKYUSHO
KEIO GIJUKU
KEIO GIJUKU
International Classes:
A61B3/10; A61B3/12
Domestic Patent References:
| JP2010005062A | 2010-01-14 | |||
| JP2001517978A | 2001-10-09 | |||
| JP2005514137A | 2005-05-19 |
Foreign References:
| WO2009133734A1 | 2009-11-05 |
Other References:
CONOR L. EVANS ET AL: "Chemical imaging of tissue in vino with video-rate coherent anti- Stokes Raman scattering microscop", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. Vol. 102、No. 46, JPN6016017254, 15 November 2005 (2005-11-15), pages pp. 16807-16812
T. B. HUFF ET AL: "In vivo coherent anti-Stoles Raman scattering imaging of sciatic nerve tissue", JOURNAL OF MICROSCOPY, vol. Vol. 225、Issue 2, JPN6016017256, 26 February 2007 (2007-02-26), pages pp. 175-182
MAMORU HASHIMOTO ET AL: "Three-dimensional transfer functions of coherent anti-Stokes Raman scattering microscopy", JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A, vol. Vol. 18、Issue 4, JPN6016017257, April 2001 (2001-04-01), pages pp. 771-776
ANDREAS VOLKMER ET AL: "Vibrational Imaging with High Sensitivity via Epidetected Coherent Anti-Stokes Raman Scattering Mic", PHYSICAL REVIEW LETTERS, vol. Vol. 87、No. 2, JPN6016017258, 9 July 2001 (2001-07-09), pages pp.023901-1〜023901-4
CHENG LIU ET AL: "Differential imaging in coherent anti-Stokes Raman scattering microscopy with Laguerre-Gaussian exc", OPTICS EXPRESS, vol. Vol. 15、Issue 16, JPN6016017260, 6 August 2007 (2007-08-06), pages pp. 10123-10134
HENRIK NORGAARD ET AL: "Coherent anti-Stokes Raman scattering microscopy with a photonic crystal fiber based light source", OPTICS LETTERS, vol. Vol. 28、No. 13, JPN6016017262, 1 July 2003 (2003-07-01), pages pp. 1123-1125
CHRISTIAN BRACKMANN ET AL: "Visualization of β-carotene and starch granules in plant cells using CARS and SHG microscopy", JOURNAL OF RAMAN SPECTROSCOPY, vol. Vol. 42、Issue 4, JPN6016017264, April 2011 (2011-04-01), pages pp. 586-592
CHRISTIAN BRACKMANN ET AL: "Visualization of β-carotene and starch granules in plant cells using CARS and SHG microscopy", JOURNAL OF RAMAN SPECTROSCOPY, vol. Vol. 42、Issue 4, JPN6016017264, April 2011 (2011-04-01), pages pp. 586-592
CONOR L. EVANS ET AL: "Chemical imaging of tissue in vino with video-rate coherent anti- Stokes Raman scattering microscop", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. Vol. 102、No. 46, JPN6016017254, 15 November 2005 (2005-11-15), pages pp. 16807-16812
T. B. HUFF ET AL: "In vivo coherent anti-Stoles Raman scattering imaging of sciatic nerve tissue", JOURNAL OF MICROSCOPY, vol. Vol. 225、Issue 2, JPN6016017256, 26 February 2007 (2007-02-26), pages pp. 175-182
MAMORU HASHIMOTO ET AL: "Three-dimensional transfer functions of coherent anti-Stokes Raman scattering microscopy", JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A, vol. Vol. 18、Issue 4, JPN6016017257, April 2001 (2001-04-01), pages pp. 771-776
ANDREAS VOLKMER ET AL: "Vibrational Imaging with High Sensitivity via Epidetected Coherent Anti-Stokes Raman Scattering Mic", PHYSICAL REVIEW LETTERS, vol. Vol. 87、No. 2, JPN6016017258, 9 July 2001 (2001-07-09), pages pp.023901-1〜023901-4
CHENG LIU ET AL: "Differential imaging in coherent anti-Stokes Raman scattering microscopy with Laguerre-Gaussian exc", OPTICS EXPRESS, vol. Vol. 15、Issue 16, JPN6016017260, 6 August 2007 (2007-08-06), pages pp. 10123-10134
CHRISTIAN BRACKMANN ET AL: "Visualization of β-carotene and starch granules in plant cells using CARS and SHG microscopy", JOURNAL OF RAMAN SPECTROSCOPY, vol. Vol. 42、Issue 4, JPN6016017264, April 2011 (2011-04-01), pages pp. 586-592
CONOR L. EVANS ET AL: "Chemical imaging of tissue in vino with video-rate coherent anti- Stokes Raman scattering microscop", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. Vol. 102、No. 46, JPN6016017254, 15 November 2005 (2005-11-15), pages pp. 16807-16812
T. B. HUFF ET AL: "In vivo coherent anti-Stoles Raman scattering imaging of sciatic nerve tissue", JOURNAL OF MICROSCOPY, vol. Vol. 225、Issue 2, JPN6016017256, 26 February 2007 (2007-02-26), pages pp. 175-182
MAMORU HASHIMOTO ET AL: "Three-dimensional transfer functions of coherent anti-Stokes Raman scattering microscopy", JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A, vol. Vol. 18、Issue 4, JPN6016017257, April 2001 (2001-04-01), pages pp. 771-776
ANDREAS VOLKMER ET AL: "Vibrational Imaging with High Sensitivity via Epidetected Coherent Anti-Stokes Raman Scattering Mic", PHYSICAL REVIEW LETTERS, vol. Vol. 87、No. 2, JPN6016017258, 9 July 2001 (2001-07-09), pages pp.023901-1〜023901-4
CHENG LIU ET AL: "Differential imaging in coherent anti-Stokes Raman scattering microscopy with Laguerre-Gaussian exc", OPTICS EXPRESS, vol. Vol. 15、Issue 16, JPN6016017260, 6 August 2007 (2007-08-06), pages pp. 10123-10134
HENRIK NORGAARD ET AL: "Coherent anti-Stokes Raman scattering microscopy with a photonic crystal fiber based light source", OPTICS LETTERS, vol. Vol. 28、No. 13, JPN6016017262, 1 July 2003 (2003-07-01), pages pp. 1123-1125
T. B. HUFF ET AL: "In vivo coherent anti-Stoles Raman scattering imaging of sciatic nerve tissue", JOURNAL OF MICROSCOPY, vol. Vol. 225、Issue 2, JPN6016017256, 26 February 2007 (2007-02-26), pages pp. 175-182
MAMORU HASHIMOTO ET AL: "Three-dimensional transfer functions of coherent anti-Stokes Raman scattering microscopy", JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A, vol. Vol. 18、Issue 4, JPN6016017257, April 2001 (2001-04-01), pages pp. 771-776
ANDREAS VOLKMER ET AL: "Vibrational Imaging with High Sensitivity via Epidetected Coherent Anti-Stokes Raman Scattering Mic", PHYSICAL REVIEW LETTERS, vol. Vol. 87、No. 2, JPN6016017258, 9 July 2001 (2001-07-09), pages pp.023901-1〜023901-4
CHENG LIU ET AL: "Differential imaging in coherent anti-Stokes Raman scattering microscopy with Laguerre-Gaussian exc", OPTICS EXPRESS, vol. Vol. 15、Issue 16, JPN6016017260, 6 August 2007 (2007-08-06), pages pp. 10123-10134
HENRIK NORGAARD ET AL: "Coherent anti-Stokes Raman scattering microscopy with a photonic crystal fiber based light source", OPTICS LETTERS, vol. Vol. 28、No. 13, JPN6016017262, 1 July 2003 (2003-07-01), pages pp. 1123-1125
CHRISTIAN BRACKMANN ET AL: "Visualization of β-carotene and starch granules in plant cells using CARS and SHG microscopy", JOURNAL OF RAMAN SPECTROSCOPY, vol. Vol. 42、Issue 4, JPN6016017264, April 2011 (2011-04-01), pages pp. 586-592
CHRISTIAN BRACKMANN ET AL: "Visualization of β-carotene and starch granules in plant cells using CARS and SHG microscopy", JOURNAL OF RAMAN SPECTROSCOPY, vol. Vol. 42、Issue 4, JPN6016017264, April 2011 (2011-04-01), pages pp. 586-592
CONOR L. EVANS ET AL: "Chemical imaging of tissue in vino with video-rate coherent anti- Stokes Raman scattering microscop", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. Vol. 102、No. 46, JPN6016017254, 15 November 2005 (2005-11-15), pages pp. 16807-16812
T. B. HUFF ET AL: "In vivo coherent anti-Stoles Raman scattering imaging of sciatic nerve tissue", JOURNAL OF MICROSCOPY, vol. Vol. 225、Issue 2, JPN6016017256, 26 February 2007 (2007-02-26), pages pp. 175-182
MAMORU HASHIMOTO ET AL: "Three-dimensional transfer functions of coherent anti-Stokes Raman scattering microscopy", JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A, vol. Vol. 18、Issue 4, JPN6016017257, April 2001 (2001-04-01), pages pp. 771-776
ANDREAS VOLKMER ET AL: "Vibrational Imaging with High Sensitivity via Epidetected Coherent Anti-Stokes Raman Scattering Mic", PHYSICAL REVIEW LETTERS, vol. Vol. 87、No. 2, JPN6016017258, 9 July 2001 (2001-07-09), pages pp.023901-1〜023901-4
CHENG LIU ET AL: "Differential imaging in coherent anti-Stokes Raman scattering microscopy with Laguerre-Gaussian exc", OPTICS EXPRESS, vol. Vol. 15、Issue 16, JPN6016017260, 6 August 2007 (2007-08-06), pages pp. 10123-10134
CHRISTIAN BRACKMANN ET AL: "Visualization of β-carotene and starch granules in plant cells using CARS and SHG microscopy", JOURNAL OF RAMAN SPECTROSCOPY, vol. Vol. 42、Issue 4, JPN6016017264, April 2011 (2011-04-01), pages pp. 586-592
CONOR L. EVANS ET AL: "Chemical imaging of tissue in vino with video-rate coherent anti- Stokes Raman scattering microscop", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. Vol. 102、No. 46, JPN6016017254, 15 November 2005 (2005-11-15), pages pp. 16807-16812
T. B. HUFF ET AL: "In vivo coherent anti-Stoles Raman scattering imaging of sciatic nerve tissue", JOURNAL OF MICROSCOPY, vol. Vol. 225、Issue 2, JPN6016017256, 26 February 2007 (2007-02-26), pages pp. 175-182
MAMORU HASHIMOTO ET AL: "Three-dimensional transfer functions of coherent anti-Stokes Raman scattering microscopy", JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A, vol. Vol. 18、Issue 4, JPN6016017257, April 2001 (2001-04-01), pages pp. 771-776
ANDREAS VOLKMER ET AL: "Vibrational Imaging with High Sensitivity via Epidetected Coherent Anti-Stokes Raman Scattering Mic", PHYSICAL REVIEW LETTERS, vol. Vol. 87、No. 2, JPN6016017258, 9 July 2001 (2001-07-09), pages pp.023901-1〜023901-4
CHENG LIU ET AL: "Differential imaging in coherent anti-Stokes Raman scattering microscopy with Laguerre-Gaussian exc", OPTICS EXPRESS, vol. Vol. 15、Issue 16, JPN6016017260, 6 August 2007 (2007-08-06), pages pp. 10123-10134
HENRIK NORGAARD ET AL: "Coherent anti-Stokes Raman scattering microscopy with a photonic crystal fiber based light source", OPTICS LETTERS, vol. Vol. 28、No. 13, JPN6016017262, 1 July 2003 (2003-07-01), pages pp. 1123-1125
Attorney, Agent or Firm:
Shinichi Abe
Yoshihiro Shimizu
Yuji Tsujida
Kazunori Fujie
Ichiro Kaneko
Yoshihiro Shimizu
Yuji Tsujida
Kazunori Fujie
Ichiro Kaneko