MACROCYCLIC PEPTIDE ACTIVE AGAINST THE HEPATITIS C VIRUS

Title:

MACROCYCLIC PEPTIDE ACTIVE AGAINST THE HEPATITIS C VIRUS

Document Type and Number:

Japanese Patent JP2011006420

Kind Code:

A

Abstract:

To provide an NS3 protease-inhibitive new compound.

There are provided a new peptide analog which is a macrocyclic compound advantageous as an HCV (hepatitis C virus) NS3 protease inhibitor, a pharmaceutical composition containing such an analog and a method of using such an analog in the treatment of HCV infection. The compound specifically inhibits NS3 protease and exhibits no significant suppressing activity against other serine proteases.

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WO/2014/144004	PEPTIDES WITH ANTIFUNGAL ACTIVITY AND METHODS OF USING THE PEPTIDES

Inventors:

LLINAS-BRUNET MONTSE
BAILEY MURRAY
BHARDWAJ PUNIT
FORGIONE PASQUALE
GHIRO ELISE
GOUDREAU NATHALIE
HALMOS TEDDY
RANCOURT JEAN

Application Number:

JP2010156015A

Publication Date:

January 13, 2011

Filing Date:

July 08, 2010

Export Citation:

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Assignee:

BOEHRINGER INGELHEIM INT

International Classes:

C07K5/00; A61K38/00; A61K38/06; A61K38/12; A61P31/12; A61P31/14; A61P43/00; C07K5/08; C07K5/087; C07K5/12; C07K11/00; C12N9/99

Domestic Patent References:

JP2002542160A	2002-12-10
JP4398424B2	2010-01-13
JP4704342B2	2011-06-15

Foreign References:

WO2003053349A2	2003-07-03
WO2003064455A2	2003-08-07
WO2003066103A1	2003-08-14

Other References:

JPN6008051862; Ａｎｇｅｗ．Ｃｈｅｍ．Ｉｎｔ．Ｅｄ．Ｅｎｇｌ．，Ｖｏｌ．４２，Ｎｏ．１２（２００３．Ｍａｒ．）ｐ．１３５６-１３６０

Attorney, Agent or Firm:

Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai

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