LONG ACTING BIOLOGICALLY ACTIVE CONJUGATE

Japanese Patent JP2011006419

A

To provide biologically active compounds that is reacted with a polymer, such as albumin, to form covalent linked complexes wherein the resulting complexes exhibit a desired biological activity in vivo.

The complexes are produced by conjugating a biologically active moiety, for example, a renin inhibitor or a viral fusion inhibitor peptide, with purified and isolated protein. The complexes have extended lifetimes in the bloodstream as compared to the unconjugated molecule, and exhibit biological activity for extended periods of time as compared to the unconjugated molecule. The complexes are inhibitors of viral infection and/or exhibit anti-fusion characteristic. In particular, the compounds have inhibiting activity against viruses such as human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) and have extended duration of action for the treatment of viral infections.

JPH10324700	NEW ANTI-HIV CONJUGATE AND MEDICINAL COMPOSITION
WO/1987/004721	SOR GENE PRODUCT FROM HUMAN T-CELL LYMPHOTROPIC VIRUS III
JP4418101	Attenuated vifDNA immunization cassette for gene vaccine

SILVA ABELARDO
ERICKSON JOHN E
EISSENSTAT MICHAEL
AFONINA ELENA
GULNIK SERGEI

JP2010153334A

January 13, 2011

July 05, 2010

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SEQUOIA PHARMACEUTICALS INC

C07K14/155; A61K38/00; A61K47/48; A61P31/12; A61P43/00; C07K14/00; C07K14/76; C07K14/765; C07K16/00; C07K19/00; C08G

JPS59231055A	1984-12-25
JPH03500880A	1991-02-28
JPS63215657A	1988-09-08

WO2000076550A2	2000-12-21
WO2002089776A1	2002-11-14
WO1993023062A1	1993-11-25
WO2002096935A2	2002-12-05
WO2002038609A2	2002-05-16

Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito
Omori Miko

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