Title:
MANUFACTURE OF 2-(E)-PHENYLMETHYLENECYCLOHEPTAN- 1-ONE-(E)-OXIME
Document Type and Number:
Japanese Patent JPS58208262
Kind Code:
A
Abstract:
A process for the preparation of 2-/E/-phenylmethylenecycloheptan-1- one-/E/-oxime of the formula /I/ free of other isomers comprises reacting 2-/E/-phenylmethylenecycloheptan- 1-one of the formula /II/ with hydroxylamine obtained "in situ" from a hydroxylamine salt in the presence of a base. The reaction is carried out in water and/or in a lower, with water unrestrictedly miscible, aliphatic alcohol, and subsequently the alcohol content of the reaction medium is adjusted to 40-60%. The compound of the formula /I/ is isolated from the reaction mixture by known methods. The 2-/E/-phenylmethylenecycloheptan- 1-one-/E/-oxime of the formula /I/serves as intermediate for the synthesis of compounds possessing valuable pharmaceutical properties.
Inventors:
ZORUTAN BUDAI
CHIBOORU MEZEI
RASUZURO REI NE ARANKA KONYA
CHIBOORU MEZEI
RASUZURO REI NE ARANKA KONYA
Application Number:
JP5680983A
Publication Date:
December 03, 1983
Filing Date:
March 31, 1983
Export Citation:
Assignee:
EGYT GYOGYSZERVEGYESZETI GYAR
International Classes:
C07C251/44; A61K31/15; C07C67/00; C07C239/00; A61K; C07C; (IPC1-7): C07C131/08
Attorney, Agent or Firm:
Hideto Asamura