Title:
MANUFACTURING METHOD OF TELMISARTAN-CONTAINING GRANULATED MATERIAL
Document Type and Number:
Japanese Patent JP2014177445
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for manufacturing a solid preparation containing poorly water-soluble telmisartan, the method capable of industrially inexpensively and rapidly manufacturing a granulated material in which telmisartan can be released and dissolved quickly even in a neutral pH range, without tableting disorder, by compression tableting processes.SOLUTION: In manufacturing processes of granules, use of a solution in which telmisartan is dissolved in an aqueous solution of pH 10.0 to 13.5 containing a basic amino acid and an inorganic base can release and dissolve telmisartan quickly within a gastrointestinal tract, and thereby granulated materials can be industrially inexpensively and rapidly manufactured without tableting disorder by compression tableting processes. L-arginine is preferred as a basic amino acid, and sodium hydroxide is preferred as an inorganic base.
Inventors:
GOCHOMORI KAZUHIRO
TANIGUCHI TOSHIYA
TANIGUCHI TOSHIYA
Application Number:
JP2013120419A
Publication Date:
September 25, 2014
Filing Date:
June 07, 2013
Export Citation:
Assignee:
OHARA YAKUHIN KOGYO KK
International Classes:
A61K31/4184; A61K9/16; A61K9/20; A61K47/02; A61K47/18
Attorney, Agent or Firm:
Valley Yoshitaka
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