Title:
ＢＲＡＦ陽性癌を患っている患者を、ＢＲＡＦ阻害剤に対する非レスポンダーであると及びＭＡＰＫ／ＥＲＫ阻害剤に対するレスポンダーであると同定する手段及び方法
Document Type and Number:
Japanese Patent JP7036594
Kind Code:
B2
Abstract:
The present invention relates to the field of diagnostics, in particular, cancer diagnostics. More specifically, it relates to a method for identifying whether a subject suffering from a BRAF-positive cancer is a non-responder to a BRAF inhibitor, or not, and/or is a responder to an MAPK/ERK inhibitor, a method for diagnosing cancer, a method for assessing responsiveness to targeted therapy in a subject and a method for assessing cancer in a subject. Moreover, contemplated by the invention are a kit and a device for diagnosing cancer. Further, the invention relates to a MAPK/ERK inhibitor for use in treating a subject suffering from a BRAF-positive cancer.
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Inventors:
Mitchell Paul Rebec
Reinhard Dunmer
Daniel Bidmar
Marieke Vervoor Gorthoches Laai Macels
Reinhard Dunmer
Daniel Bidmar
Marieke Vervoor Gorthoches Laai Macels
Application Number:
JP2017522732A
Publication Date:
March 15, 2022
Filing Date:
July 13, 2015
Export Citation:
Assignee:
Universitate Zurich Prolectrat Membe
International Classes:
C12Q1/6827; A61K45/00; A61P35/00; A61P43/00; C12N15/12; C12Q1/6806; C12Q1/6886; G01N33/53; G01N33/574
Domestic Patent References:
| JP2013543008A |
Foreign References:
| WO2012068562A2 |
Other References:
J.Mol.Diagn.,2013年,Vol.15,No.1,pp.94-100
Nature,2010年,Vol.468,No.7326,pp.973-977
MOLECULAR CANCER THERAPEUTICS,2012年4月1日,Vol.11,No.4,pp.909-920
Cancer Res.,2003年,Vol.63,No.15,pp.4561-4567
Nature,2010年,Vol.468,No.7326,pp.973-977
MOLECULAR CANCER THERAPEUTICS,2012年4月1日,Vol.11,No.4,pp.909-920
Cancer Res.,2003年,Vol.63,No.15,pp.4561-4567
Attorney, Agent or Firm:
Aoki Atsushi
Shinji Mihashi
Junichi Tsuruta
Tomohiro Nanzan
Youichi Watanabe
Naonori Koda
Shinji Mihashi
Junichi Tsuruta
Tomohiro Nanzan
Youichi Watanabe
Naonori Koda