Title:
放射性ハロゲンを備えた化合物の大量標識の機構およびその方法
Document Type and Number:
Japanese Patent JP2004536092
Kind Code:
A
Abstract:
Disclosed are methods for manufacturing radiohalogen-labeled steroids, nucleosides, nucleotides and proteins, for example, pyrimidines and proteins. Methods according to the example embodiments specific to pyrimidines includes dissolving a halogenated pyrimidine to obtain an initial solution, adding bis(tributyltin) and triphenylphosphine palladium to produce a catalyzed solution, heating the catalyzed solution under conditions sufficient to induce a reaction that produces an intermediate solution including a stannylated pyrimidine compound, removing substantially all of the first solvent from the intermediate solution to obtain an intermediate composition, purifying the resulting solution to obtain a purified composition including a stannylated pyrimidine, reacting the stannylated pyrimidine compound with a radiohalogen in a buffered reaction mixture to produce the radiohalogenated pyrimidine, adding an antioxidant and extracting the radiohalogenated pyrimidine from the reaction mixture. The extracted radiohalogenated pyrimidine(s) may be utilized in forming diagnostic and/or therapeutic products.
Inventors:
Liu, Jiang Min
Application Number:
JP2003506916A
Publication Date:
December 02, 2004
Filing Date:
June 25, 2002
Export Citation:
Assignee:
The University of Alberta, The University of British Columbia, Carlton University, Simon Fraser University and The University of Victory
International Classes:
C07H19/073; A61K51/04; C07H19/06; C07J1/00; C07J7/00; C07K1/13; C07K16/26; G01N33/534; (IPC1-7): C07H19/073; C07J1/00; C07J7/00; C07K1/13; C07K16/26
Attorney, Agent or Firm:
Kenzo Hara
Ryuichi Kijima
Ichiro Kaneko
Ryuichi Kijima
Ichiro Kaneko
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