Title:
MEDICINAL COMPOSITION CONTAINING OPTICALLY PURE TERFENADINECARBOXYLATE AND USED FOR TREATING ALLERGIC DISEASE
Document Type and Number:
Japanese Patent JP3288662
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject composition capable of avoiding cardiovascular system side effects such as QT extension and ventricular arhythmia caused by the administration of terfenadine by adding a specific optically pure terfenadine carboxylate.
SOLUTION: This medicinal composition contains an optically pure R-(+)- terfenadine carboxylate {R-(+)-4-[1-hydroxy-4-(4-hydroxydiphenylmethyl-1- piperidinyl)butyl]-α,α-dimethylbenzene acetic acid methyl ester, R-(+)-4-[1- hydroxy-4-(4-hydroxydiphenylmethyl-1-piperidinyl)butyl]-α, α-dimethylbenzene acetic acid, R-(+)-1-[p-(2-hydroxymethylprop-2-yl)-phenyl]-4-[4-(α-hydroxy-α- phenylvenzel)piperidin-1-yl]butanol, etc.}, which does not contain a S(-)- stereoisomer. The compound of the formula (Z is COOH, etc.), is preferably administered at a daily dose of 0.01-500 mg.
Inventors:
Young, James W.
Gray, Nancy M.
Wolseley, Raymond Elle.
Chen, Ewan
Gray, Nancy M.
Wolseley, Raymond Elle.
Chen, Ewan
Application Number:
JP29122899A
Publication Date:
June 04, 2002
Filing Date:
August 03, 1993
Export Citation:
Assignee:
Sepra Core, Incorporated
International Classes:
C07D211/22; A61K9/48; A61K31/137; A61K31/165; A61K31/192; A61K31/445; A61K31/451; A61K31/60; A61K45/00; A61K45/06; A61P17/00; A61P27/16; A61P37/08; A61P43/00; (IPC1-7): A61K31/445; A61K45/00; A61P37/08
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)