To carry out intensive studies on synthesis and a pharmacological activity of a substituted benzene compound in order to find out a compound having an excellent binding activity for an LXR (liver X receptor) and to provide an excellent LXR modulator which is the substituted benzene compound having a specific structure and the excellent binding activity for the LXR.
The compound, etc., are represented by general formula (I) [wherein, R1 is a -COR9 (wherein, R9 is an alkyl, a substitutable alkoxy, a substitutable amino or the like), a substitutable aryl or the like; R2 is an H, an OH, an alkoxy or the like; R3 is an H, a substitutable alkyl, a substitutable alkenyl, a substitutable alkoxy, a substitutable amino or the like; R4 and R5 are each an H, a substitutable alkyl, a halogeno or the like; R6 and R7 are each an H, an alkyl or the like; R8 is an -N(R10)ZR11, a -ZN(R10)R12, an -X2N(R10)ZR11 or the like (wherein, R10 is an H, a substitutable alkyl or the like; R11 is an H, a substitutable alkyl, a substitutable cycloalkyl, a substitutable alkenyl, a substitutable alkoxy, a substitutable amino, a substitutable phenyl or the like; R12 is an H, a substitutable alkyl, a substitutable alkenyl or the like; X2 is an alkylene; Z is a CO, a CS or an SO2); X1 is a single bond or a substitutable methylene; and Y is a substitutable phenyl or a substitutable heterocyclyl]. Furthermore, a pharmaceutical composition comprises the compound, etc.
YOSHIDA MASAYUKI
TAMAKI KAZUHIKO
Reiko Kanehara
Yuki Echigo