Title:
メタロ−β−ラクタマーゼ阻害剤
Document Type and Number:
Japanese Patent JP5583739
Kind Code:
B2
Abstract:
A phthalic acid derivative represented by the general formula (1) has an inhibitory activity on metallo-ß-lactamase. Therefore, when used in combination with a ß-lactam antibiotic, the derivative can inhibit the deactivation of the ß-lactam antibiotic against a bacterium capable of producing metallo-ß-lactamase and can recover the antibacterial activity of the ß-lactam antibiotic. (I) wherein R1 represents a hydroxy group, a C1-7 alkyl group, a C1-7 alkoxy group, or a saturated or unsaturated heterocyclic ring (provided that each of these groups may have a substituent); R2 represents a hydrogen atom, or a C1-7 alkyl group (provided that each of these groups may have a substituent); R3 represents a hydrogen atom, a C1-7 alkyl group, a halogen atom, an amino group, or a piperidine ring (provided that each of these groups may have a substituent); and M1 and M2 independently represent a hydrogen atom, a pharmaceutically acceptable cation, or a pharmaceutically acceptable group capable of being hydrolyzed in vivo.
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Inventors:
Yukiko Hiraiwa
Ida 瑞代
Toshiaki Kudo
Inside of the peak Akihiro
Ken Konnai
Woods Ken-ichiro
Ida 瑞代
Toshiaki Kudo
Inside of the peak Akihiro
Ken Konnai
Woods Ken-ichiro
Application Number:
JP2012258925A
Publication Date:
September 03, 2014
Filing Date:
November 27, 2012
Export Citation:
Assignee:
Meiji Seika ファルマ, Inc.
International Classes:
C07D211/46; C07C65/21; C07D211/34; C07D211/62; A61K31/194; A61K31/445; A61K45/00; A61P31/04; A61P43/00
Attorney, Agent or Firm:
Katsunuma Hirohito
Yukitaka Nakamura
Nobutaka Yokota
Takehiro Ito
Omori Michiko
Yukitaka Nakamura
Nobutaka Yokota
Takehiro Ito
Omori Michiko