METHOD FOR DIASTEREOSELECTIVELY SYNTHESIZING NUCLEOSIDE

Japanese Patent JP3704055

B2

PROBLEM TO BE SOLVED: To obtain a new intermediate useful for a method for diastereoselective synthesis for preparing optically active cis-nucleosides, nucleoside analogs and derivatives.
SOLUTION: This intermediate is represented by the formula (I), wherein, W and X are each S, S=O, SO2 or O; and R3 is hydrogen or carbonyl substituted with hydroxyl, a trialkylsilyl, an alkyl, an aralkyl, an alkoxy, amine, a thiol, an aryl, an alkenyl or an alkynyl, 1,2-dicarbonyl substituted with an alkyl or an aryl, an anhydride substituted with an alkyl or an aryl, azomethine substituted with hydrogen, an alkyl, an alkoxy or a dialkylamino at the nitrogen and substituted with hydrogen, an alkyl or an alkoxy at the carbon or thiocarbonyl substituted with hydroxyl, an alkoxy or a thiol.

Tarekman Sur
Haorn Jin
Alan H. L. Tse
M. Arshad Sidiki

JP2001136217A

October 05, 2005

May 21, 1992

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Shire Biochem Inc.

A61K31/513; A61P31/12; B01J31/02; C07B53/00; C07H19/00; C07B61/00; C07C13/10; C07D207/00; C07D231/04; C07D233/02; C07D261/02; C07D263/04; C07D275/02; C07D277/04; C07D285/04; C07D291/04; C07D307/04; C07D307/16; C07D307/18; C07D307/24; C07D317/08; C07D317/24; C07D317/32; C07D317/34; C07D323/02; C07D327/04; C07D333/48; C07D339/02; C07D339/06; C07D341/00; C07D403/04; C07D405/04; C07D407/04; C07D409/04; C07D411/04; C07D411/12; C07D411/14; C07D413/04; C07D419/04; C07D471/00; C07D473/00; C07D473/06; C07D473/30; C07D473/34; C07H19/04; C07H19/06; C07H19/16; C07D; (IPC1-7): C07D327/04; C07D317/34; C07D407/04; C07D411/04

JP51146342A

Bulletin of the Chemical Society of Japan,(1972),45(3),p.913-5

Aoyama Aoi
Mitsutaka Iwasaki

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