Title:
METHOD OF PREPARING OPTICALLY ACTIVE CYANOHYDRINS
Document Type and Number:
Japanese Patent JP3253150
Kind Code:
B2
Abstract:
PURPOSE: To readily obtain the subject cyanohydrins in a relatively high optical purity and yield by adding hydrogen cyanide to a carbonyl compound in the presence of hydroxynitrile lyase, under a specific condition.
CONSTITUTION: A homogeneous aqueous solution of hydroxynitrile lyase is buffered with an acetate buffer having a buffer concentration of 0.005-0.1 mol/L or with a non-acetate buffer. An adding reaction of hydrogen cyanide to a carbonyl compound (aldehydes or ketones) is performed in a two-phase solvent system in which a volume ratio of an organic solvent at least substantially non-miscible with water to the homogeneous aqueous solution is about 5/1-about 1/5. A solution of hydrogen cyanide and a solution of the carbonyl compound in an organic solvent are properly mixed during the reaction period with the homogeneous aqueous solution of hydroxynitrile lyase.
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Inventors:
Hendrik D'Abrieu Gelk
Vibrant Tay Loin
Vibrant Tay Loin
Application Number:
JP35136792A
Publication Date:
February 04, 2002
Filing Date:
December 08, 1992
Export Citation:
Assignee:
DUPHAR INTERNATIONAL RESEARCH BESLOTEN VENNOOTSHAP
International Classes:
C12P13/00; C12P17/04; (IPC1-7): C12P13/00
Domestic Patent References:
| JP63219388A |
Attorney, Agent or Firm:
Heikichi Odashima
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