Title:
心不全非ヒト霊長類モデル動物の製造方法
Document Type and Number:
Japanese Patent JP7374455
Kind Code:
B2
Abstract:
To provide a production method of a heart failure nonhuman primate model animal using a primate that is an animal closer to a human; and to provide an evaluation method of a material having activity of treatment or prevention of a heart failure using the heart failure nonhuman primate model animal.SOLUTION: A production method of a heart failure nonhuman primate model animal includes a step for administering an anthracycline anti-tumor agent to a nonhuman primate, while increasing stepwise so that a total dose agrees with 400-1,000 mg/m2 body surface area. An evaluation method of a material having activity of treatment or prevention of a heart failure includes a step for administering a test substance to the heart failure nonhuman primate model animal produced by the production method.SELECTED DRAWING: None
Inventors:
Hisakazu Ogida
Akira Sato
Akira Sato
Application Number:
JP2019125286A
Publication Date:
November 07, 2023
Filing Date:
July 04, 2019
Export Citation:
Assignee:
Shiga University of Medical Science
International Classes:
A01K67/027; G01N33/15; G01N33/50
Other References:
HERMAN, E. H. et al.,Animal models of anthracycline cardiotoxicity:Basic mechanisms and cardioprotective activity,Progress in Pediatric Cardiology,8(2),1998年,pp.49-58,ISSN.1058-9813
SIEBER, S. M. et al.,Cardiotoxic and possible leukemogenic effects of adriamycin in nonhuman primates,Pharmacology,20(1),1980年,pp.9-14
TAKAYAMA, S, et al.,Chemical carcinogenesis studies in nonhuman primates,Proceedings of the Japan Academy. Series B, Physical and biological sciences,84(6),2008年,pp.176-188
SIEBER, S. M. et al.,Cardiotoxic and possible leukemogenic effects of adriamycin in nonhuman primates,Pharmacology,20(1),1980年,pp.9-14
TAKAYAMA, S, et al.,Chemical carcinogenesis studies in nonhuman primates,Proceedings of the Japan Academy. Series B, Physical and biological sciences,84(6),2008年,pp.176-188
Attorney, Agent or Firm:
Saegusa International Patent Office
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