Title:
ヒト組織因子(TF)に対するヒト型化抗体およびヒト型化抗体の作製方法
Document Type and Number:
Japanese Patent JP3998419
Kind Code:
B2
Abstract:
A humanized antibody against tissue factor (TF), comprising:
A: a humanized H chain comprising (1) a H chain V region comprising the H chain CDRs of a mouse monoclonal antibody against TF and the H chain FRs of a human antibody, and (2) the H chain C region of a human antibody; and
B: a humanized L chain comprising (1) an L chain V region comprising the L chain CDRs of a mouse monoclonal antibody against TF and the L chain FRs of a human antibody, and (2) the L chain C region of a human antibody. After generating a humanized V region by grafting the CDRs of a mouse monoclonal antibody onto a human antibody, a humanized antibody having a higher activity is searched by replacing the FR of the above region with the corresponding FR of the human antibody having a high homology.
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Inventors:
Isao Sato
Hideki Adachi
Naohiro Yabuta
Hideki Adachi
Naohiro Yabuta
Application Number:
JP2000542456A
Publication Date:
October 24, 2007
Filing Date:
April 02, 1999
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C12P21/08; C07K16/28; C07K16/36; C12N5/10; C12N15/02; C12N15/13
Domestic Patent References:
| JP1503438A |
Foreign References:
| WO1996040921A1 |
Other References:
医学のあゆみ(1993)Vol.167,No.5,p.457-462
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji