Title:
短時間加熱および急速乾燥による低溶解性活性物質をベースとする固溶体の生成法
Document Type and Number:
Japanese Patent JP5215178
Kind Code:
B2
Abstract:
A process for producing solid solutions in powder or granule form of slightly soluble substances in which the slightly soluble substance is in the form of a molecular dispersion in an excipient matrix, by atomizing a solution of the active ingredient and of the matrix excipients, which comprises heating an aqueous suspension of the slightly soluble substance in the presence of the matrix excipients to temperatures above the boiling point under atmospheric pressure, and dissolving the slightly soluble substance, and subsequently converting the solution of the slightly soluble substance and of the matrix excipients by atomizing and drying into a solid form, where the temperature of the spray solution before feeding into the atomizing apparatus is 90° C. to 350° C.
Inventors:
Colt, curl
Shane Haar, Michael
Asher, hermann
Shane Haar, Michael
Asher, hermann
Application Number:
JP2008515196A
Publication Date:
June 19, 2013
Filing Date:
May 31, 2006
Export Citation:
Assignee:
BASF SE
International Classes:
A61J3/02; A23L33/15; A61K9/14; A61K9/16; A61K47/32
Domestic Patent References:
| JP57195161A | ||||
| JP10155432A | ||||
| JP49086935A | ||||
| JP11314001A | ||||
| JP2005506442A | ||||
| JP2003534895A | ||||
| JP2002513760A | ||||
| JP2002531492A | ||||
| JP63192715A | ||||
| JP2003526666A | ||||
| JP2005519863A |
Foreign References:
| WO2005044221A1 | ||||
| US20030224043 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Ishii Teiji
Satoshi Fujita
Eiichi Arai