To obtain a prophylactic drug for treatment of asthma or bronchoconstriction in a patient necessitating treatment for adenosine depletion.

This invention relates to the prophylactic drug for treatment of asthma or bronchoconstriction of human or mammal comprising dehydroepiandrosterone, an analog thereof, or a pharmaceutically acceptable salt thereof, wherein the main component is in a size suitable for inhalation administering. The administration of folinic acid at the same time is effective.