Title:
NO供与ジクロフェナクのようなNO供与化合物の製造方法
Document Type and Number:
Japanese Patent JP2006500409
Kind Code:
A
Abstract:
The present invention relates to a new process for the preparation of NO-donating compounds using a sulfonated intermediate. The invention relates to new intermediates prepared therein suitable for large scale manufacturing of NO-donating compounds. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active NO-donating compounds. The invention further relates to a substantially crystalline form of NO-donating NSAIDs, especially 2-[2-(nitrooxy)ethoxy]ethyl {2-[(2,6-dichlorophenyl)amino]phenyl}acetate, the preparation thereof and to pharmaceutical formulations containing said crystalline form and to the use of said crystalline form in the preparation of a medicament.
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Inventors:
Anderson, Johann
Belli, Aldo
Cannata, Vinsenzo
Hedberg, Martin
Palm Glen, Andreas
Shurdai, Siguride
Storm, malika
Villa, Marco
Belli, Aldo
Cannata, Vinsenzo
Hedberg, Martin
Palm Glen, Andreas
Shurdai, Siguride
Storm, malika
Villa, Marco
Application Number:
JP2004538109A
Publication Date:
January 05, 2006
Filing Date:
September 18, 2003
Export Citation:
Assignee:
NICOX S.A.
International Classes:
C07C201/00; C07C201/02; A61K31/216; A61P25/04; A61P29/00; C07C203/04; C07C205/40; C07C303/28; C07C309/66; C07B61/00
Attorney, Agent or Firm:
Shintaro Nogawa