Title:
METHODS AND COMPOSITIONS RELATED TO MUTANT KUNITZ DOMAIN I OF TFPI-2
Document Type and Number:
Japanese Patent JP2018093882
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a plasmin inhibitor having reduced anticoagulant activity, with respect to tumorogenesis, angiogenesis, bone remodeling, surgery, hemophilia, orthopedic surgery, coronary artery bypass grafting, and systemic inflammatory response syndrome.SOLUTION: The present invention provides a polypeptide composed of a specific amino acid sequence having at least one amino acid mutation, the polypeptide comprising substitution from leucine to arginine or lysine at position 17.SELECTED DRAWING: None
Inventors:
BAJAJ PAUL S
Application Number:
JP2018018361A
Publication Date:
June 21, 2018
Filing Date:
February 05, 2018
Export Citation:
Assignee:
UNIV CALIFORNIA
International Classes:
C12N15/09; A01K67/027; A61K38/16; A61K38/55; A61K48/00; A61P7/04; A61P9/00; A61P9/10; A61P19/08; A61P29/00; A61P35/00; A61P41/00; A61P43/00; C07K14/81; C12N9/99
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita